Correlation of Adenosine Deaminase Activity with Glycated Hemoglobin Levels in Type II Diabetes Mellitus
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Date
2024-06
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Publisher
International Society for Contemporary Medical Research
Abstract
Introduction: Diabetes mellitus is not a single disease entity but rather a group of metabolic disorders characterized by hyperglycemia which results from defects in insulin secretion, insulin action or most commonly both. The chronic hyperglycemia and attendant metabolic dysregulation may be associated with secondary damage in multiple organ systems, especially the kidneys, eyes, nerves and blood vessels. Materials and methods: The present study includes 90 subjects, of which 60 were cases of type 2 DM from Department of Endocrinology, Osmania General Hospital. Investigations were performed at the Department of Biochemistry, Osmania Medical College/ Osmania General Hospital; Hyderabad and results were analyzed. Results: A total of 90 patients were recruited for the study which included 30 Type II Diabetes mellitus patients with glycated hemoglobin ? 7 %, 30 Type II Diabetes mellitus with glycated hemoglobin < 7% and 30 healthy individuals as controls. The following parameters were analyzed.1. Fasting plasma glucose, 2.Glycated hemoglobin (HbA1C), 3.Serum Adenosine deaminase, 4. Serum uric acid The data was analyzed using Graph Pad Prism software version 7.0. Descriptive results are expressed as mean and SD of various parameters in different groups. Conclusions: There is clear cut elevation of serum ADA in Type 2 Diabetes mellitus. But due to short half life and diurnal variations of ADA, to establish ADA as a routine diagnostic and prognostic marker in the laboratory, substantial number of samples have to be analyzed in larger and more elaborate studies.
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Keywords
Fasting blood glucose, Hyperglycemia, Insulin, Metabolic dysregulation, Uric acid.
Citation
Siddiqui Azra, Siddiqui Aqeelah Mohammed, Siddiqui Mohammed Abdul Mujeeb, Devi M. Uma . Correlation of Adenosine Deaminase Activity with Glycated Hemoglobin Levels in Type II Diabetes Mellitus. International Journal of Contemporary Medical Research. 2024 Jun; 11(6): 1-5