Synthesis and in vivo Anti-inflammatory and Analgesic activities of Oxadiazoles clubbed with Benzothiazole nucleus.

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dc.contributor.authorKumar, Vishal
dc.contributor.authorSharma, Saurabh
dc.contributor.authorHusain, Asif
dc.date.accessioned2015-12-14T04:47:46Z
dc.date.available2015-12-14T04:47:46Z
dc.date.issued2015
dc.description.abstractThe aim of the present work is to synthesize and evaluate the anti-inflammatory and analgesic activity of 2-(5-substituted-1,3,4-oxadiazole-2-yl)-1,3-benzathiazole derivatives. In the present investigation, a series of 2-(5-substituted-1,3,4-oxadiazole-2-yl)-1,3-benzathiazole derivatives (3a1-3a9) were synthesized by condensing benzothiazolyl carboxyhydrazide and appropriate aryl acids in the presence of phosphorous oxychloride. Structures of synthesized compounds were established on the basis of IR, 1H NMR, and Mass spectroscopy. All the synthesized compounds were screened for their in-vivo anti-inflammatory and analgesic activities at the dose of 50 mg/kg and 10 mg/kg po. The biological result shows that some compounds were good in their anti-inflammatory and analgesic actions.en_US
dc.identifier.citationKumar Vishal , Sharma Saurabh, Husain Asif. Synthesis and in vivo Anti-inflammatory and Analgesic activities of Oxadiazoles clubbed with Benzothiazole nucleus. International Current Pharmaceutical Journal. 2015; 4(112): 457-461.en_US
dc.identifier.issn2224-9486
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/168011
dc.language.isoenen_US
dc.source.urihttps://www.banglajol.info/index.php/ICPJ/article/view/25597en_US
dc.subject1,3,4-oxadiazole derivativesen_US
dc.subjectsynthesisen_US
dc.subjectaryl acidsen_US
dc.subjectanti-inflammatory activityen_US
dc.subjectanalgesic activityen_US
dc.subjectspectroscopyen_US
dc.titleSynthesis and in vivo Anti-inflammatory and Analgesic activities of Oxadiazoles clubbed with Benzothiazole nucleus.en_US
dc.typeArticleen_US
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