Synthesis, biological evaluation and molecular docking of aryl hydrazines and hydrazides for anticancer activity.
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Date
2010-03
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Abstract
Aryl hydrazine and hydrazide analogues were synthesized based on p-tolyl hydrazine, isolated as a breakdown product of a secondary metabolite from the mushroom, Agaricus bisporus, and tested to be highly active molecule than 5-fluorouracil in in vitro anticancer studies. The synthesized analogues were tested for anticancer activity using NCI protocol. Anolgues 12 and 15 emerged as molecules with significant in vitro anticancer activity. Molecular docking study revealed the binding orientations of aryl hydrazines and hydrazides analogues in the active sites of thymidylate synthase.
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Keywords
Anticancer activity, Aryl hydrazides, Aryl hydrazines, Molecular docking
Citation
Gohil Vikrantsinh M, Agrawal Satyam K, Saxena Ajit K, Garg Divita, Gopimohan C, Bhutani Kamlesh K. Synthesis, biological evaluation and molecular docking of aryl hydrazines and hydrazides for anticancer activity. Indian Journal of Experimental Biology. 2010 Mar; 48(3): 265-268.