Recovery from reperfusion injury in intact canine heart by nifedipine.

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dc.contributor.authorSeth, S Den_US
dc.contributor.authorMaulik, S Ken_US
dc.contributor.authorManchanda, S Cen_US
dc.contributor.authorMaulik, M Gen_US
dc.contributor.authorReddy, K Sen_US
dc.contributor.authorGupta, Y Ken_US
dc.date.accessioned2009-05-28T11:37:47Z
dc.date.available2009-05-28T11:37:47Z
dc.date.issued1993-12-01en_US
dc.description.abstractEffect of nifedipine post-treatment (100 micrograms/kg slow bolus followed by 3 micrograms/kg/min infusion) on the functional and metabolic changes of the heart after a brief regional ischemia (I) (20 min.) followed by 1 hr of reperfusion (R) was studied in pentobarbitone-anaesthetized open-chest coronary ligated dogs. In the control group, 1 hr of reperfusion failed to cause any significant recovery of the depressed LVdP/dtmax and that of the elevated LVEDP (LVdP/dtmax, pre-ischemic: 2720 +/- 90 mm Hg/sec., 20 min. of I: 2410 +/- 120 mm Hg/sec and 60 min. of R: 2210 +/- 130 mm Hg/sec. LVEDP, pre-ischemic: 5.25 +/- 0.2 mm Hg, 20 min. of I: 10.5 +/- 0.9 mm Hg and 60 min. of R: 7.5 +/- 0.5 mm Hg). However, 1 hr of reperfusion caused a significant recovery of ischemia-induced depletion of myocardial creatine phosphate (CP) content only, but not that of ATP. On post-treatment with nifedipine (i.e., infusion started just before reperfusion), there was a significant recovery in LVEDP (8.25 +/- 0.6 mm Hg after 20 min. of ischemia to 5.0 +/- 0.4 mm Hg after 1 hr of reperfusion) and there was no further deterioration in LVdP/dtmax, as observed in untreated dogs. More significantly, nifedipine caused a near normal recovery of both ATP and CP contents of the affected myocardium. Therefore, the present study shows that post-ischemic administration of nifedipine prevented reperfusion injury of the ischemic myocardium, as evidenced by both functional and metabolic recovery.en_US
dc.description.affiliationDepartment of Pharmacology, All India Institute of Medical Sciences, New Delhi.en_US
dc.identifier.citationSeth SD, Maulik SK, Manchanda SC, Maulik MG, Reddy KS, Gupta YK. Recovery from reperfusion injury in intact canine heart by nifedipine. Indian Journal of Experimental Biology. 1993 Dec; 31(12): 963-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/56980
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAdenosine Triphosphate --metabolismen_US
dc.subject.meshAnimalsen_US
dc.subject.meshDogsen_US
dc.subject.meshFemaleen_US
dc.subject.meshMaleen_US
dc.subject.meshMyocardial Reperfusion Injury --metabolismen_US
dc.subject.meshNifedipine --pharmacologyen_US
dc.subject.meshPhosphocreatine --metabolismen_US
dc.subject.meshVentricular Function, Left --drug effectsen_US
dc.titleRecovery from reperfusion injury in intact canine heart by nifedipine.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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