Effects of phycocyanin administration on some hormones and thermogenic factors related to metabolism in old mice

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dc.contributor.authorKORKMAZ, Didemen_US
dc.contributor.authorALKAN, ?remen_US
dc.contributor.authorYILDIZ, Hülyaen_US
dc.contributor.authorMUTLU, Ay?e Gülen_US
dc.date.accessioned2025-08-13T11:23:12Z
dc.date.available2025-08-13T11:23:12Z
dc.date.issued2025-06
dc.description.abstractMaintaining metabolic homeostasis in elderly individuals is crucial for preventing metabolic diseases, as age-related metabolic irregularities, including insulin resistance, are common. Phycocyanin (PC), a phycobiliprotein derived from Spirulina, is known for its various bioactive properties and its applications in medicine, pharmacy, aquaculture, and the cosmetic industry. Given its potential as a nutritional supplement, this study aimed to investigate the effects of PC on key metabolic-regulating hormones; ghrelin, leptin, adiponectin, and resistin and thermogenic factors; SIRT1 and UCP1 in old mice. A total of 15 male C57BL/6 mice, aged 12-15 months, were randomly assigned to two groups: a control group (n=7) and a phycocyanin-administered group (n=8). PC was administered through drinking water at a dose of 150 mg/kg for a period of two weeks. Blood serum and adipose tissue samples were collected for subsequent analysis of hormone and thermogenic factor levels. According to our results, PC a significant increased adiponectin levels (1.98 ng/L) and a significant decreased ghrelin levels (1.48 ng/L). Considering the metabolic changes mediated by adiponectin in muscle and liver tissue, the fact that PC increases adiponectin levels in old mice is promising that it can compensate for some metabolic irregularities, especially insulin resistance, that develop with old age. Although the clinical effect of PC in reducing ghrelin levels in aged mice is not fully known, it may be useful in preventing weight gain that occurs with aging.en_US
dc.identifier.affiliationsMolecular Biology and Genetics Department, Faculty of Science and Literature, Burdur Mehmet Akif Ersoy University, Burdur, Turkeyen_US
dc.identifier.affiliationsBiology Department, Faculty of Science and Literature, Burdur Mehmet Akif Ersoy University, Burdur, Turkeyen_US
dc.identifier.affiliationsBiology Department, Faculty of Science and Literature, Burdur Mehmet Akif Ersoy University, Burdur, Turkeyen_US
dc.identifier.affiliationsMolecular Biology and Genetics Department, Faculty of Science and Literature, Burdur Mehmet Akif Ersoy University, Burdur, Turkeyen_US
dc.identifier.citationKORKMAZ Didem, ALKAN ?rem, YILDIZ Hülya, MUTLU Ay?e Gül . Effects of phycocyanin administration on some hormones and thermogenic factors related to metabolism in old mice . Indian Journal of Experimental Biology. 2025 Jun; 63(6): 518-524en_US
dc.identifier.issn0019-5189
dc.identifier.issn0975-1009
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/253769
dc.languageenen_US
dc.publisherThe India Publications and Information Directorate (CSIR-NISCAIR)en_US
dc.relation.issuenumber6en_US
dc.relation.volume63en_US
dc.source.urihttps://doi.org/10.56042/ijeb.v63i06.12507en_US
dc.subjectSpirulinaen_US
dc.subjectAgingen_US
dc.subjectLeptinen_US
dc.subjectSIRT1en_US
dc.titleEffects of phycocyanin administration on some hormones and thermogenic factors related to metabolism in old miceen_US
dc.typeJournal Articleen_US
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