Hardy-Weinberg Equilibrium Study of Some Morphogenetic Traits in a Nigerian Population

Simple item page
dc.contributor.authorEfe, Jaiyeoba-Ojigho Jenniferen_US
dc.contributor.authorChris-Ozoko, Lilian Ebeleen_US
dc.contributor.authorTaniyohwo, Enaohwo Mamerhien_US
dc.contributor.authorAforkogene, Ubogu Josephen_US
dc.contributor.authorOkolie, Emmanuel Ikechukwuen_US
dc.contributor.authorOnyesom, Innocenten_US
dc.date.accessioned2025-05-09T07:25:09Z
dc.date.available2025-05-09T07:25:09Z
dc.date.issued2024-03
dc.description.abstractBackground: The Hardy-Weinberg (HW) equilibrium studies the distribution of allelic and genotypic frequencies within a population. It provides a mathematical benchmark for a population that is evolving and not evolving. Aim: This study investigated six morphogenetic traits among families in a Nigerian population using the Hardy- Weinberg principle with the aim of evaluating if the population was in HW equilibrium. Methodology: A total of 45 families comprising a father, mother and at least one offspring were conveniently sampled in Ogbe- Ijoh district in Delta State, Nigeria. Earlobe attachment, Hand clasping, Hitchhiker’s thumb, Leg folding, Morton’s toe and Widow’s peak were studied for their allelic and genotypic frequencies. The Chi- square test was used to analyse the association between these traits and sex, and conformance to the Mendelian inheritance pattern was evaluated with a Mendelian Chi-square. The Hardy-Weinberg equilibrium compared the allelic frequencies of parents with those of offspring. Results: Males had higher frequencies for attached earlobes, Morton’s toe and widow’s peak (35.1, 51.9, 49.4%), while the females showed a predominance for hitchhiker’s thumb, right hand clasping and leg folding (50,72.4,70.7%). There was no association between the traits and gender (p>0.05). From the Mendelian Chi-square, free earlobe, right-hand clasping, right leg folding, Morton’s toe (SBt), the recessive phenotype of hitchhiker’s thumb as well as widow’s peak were the dominant traits in the studied population (X2 < 3.841 ). The H-W equation revealed a deviation of the offspring’s genotype from those of the parents for earlobe, hand clasping, leg folding, Morton’s toe and widow’s peak (1:1:2 [1:1; 4]; 2: 1: 3 [1:1:2]; 3:1:3 [1:1:2]; 5: 1: 4 [6:1:5}; 5:1:4 [7: 1:5]). However, parental and offspring alleles were identical for hitchhiker’s thumb (5:1:5 [5:1: 5]). The homozygotes for both parents and offspring outnumbered the heterozygotes for all traits (295: 245; 156: 119). Conclusion: The study showed that only the hitchhiker’s thumb was in HW equilibrium, suggesting that evolution may not occur at that locus.en_US
dc.identifier.affiliationsDepartment of Human Anatomy, Faculty of Basic Medical Sciences, Delta State University, Abraka, Nigeriaen_US
dc.identifier.affiliationsDepartment of Human Anatomy, Faculty of Basic Medical Sciences, Delta State University, Abraka, Nigeriaen_US
dc.identifier.affiliationsDepartment of Human Anatomy, Faculty of Basic Medical Sciences, Delta State University, Abraka, Nigeriaen_US
dc.identifier.affiliationsDepartment of Human Anatomy, Faculty of Basic Medical Sciences, Delta State University, Abraka, Nigeriaen_US
dc.identifier.affiliationsDepartment of Nursing and Midwifery, University of Central Lancashire, Preston, Englanden_US
dc.identifier.affiliationsMalaria Research Unit, Department of Biochemistry, Faculty of Basic Medical Sciences, Delta State University, Abraka, Nigeriaen_US
dc.identifier.citationEfe Jaiyeoba-Ojigho Jennifer, Chris-Ozoko Lilian Ebele, Taniyohwo Enaohwo Mamerhi, Aforkogene Ubogu Joseph, Okolie Emmanuel Ikechukwu, Onyesom Innocent . Hardy-Weinberg Equilibrium Study of Some Morphogenetic Traits in a Nigerian Population . International Journal of Anatomy and Research. 2024 Mar; 12(1): 8840-8848en_US
dc.identifier.issn2321-4287
dc.identifier.issn2321-8967
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/243203
dc.languageenen_US
dc.publisherIMED Research Publicationsen_US
dc.relation.issuenumber1en_US
dc.relation.volume12en_US
dc.source.urihttps://dx.doi.org/10.16965/ijar.2023.259en_US
dc.subjectHardy-Weinberg equilibriumen_US
dc.subjectMendelen_US
dc.subjectTraitsen_US
dc.subjectNigeriaen_US
dc.subjectPopulationen_US
dc.titleHardy-Weinberg Equilibrium Study of Some Morphogenetic Traits in a Nigerian Populationen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
ijar2024v12n1p8840.pdf
Size:
991.09 KB
Format:
Adobe Portable Document Format
Download
Collections
International Journal of Anatomy and Research