Cystatin C: A Better Predictor of Kidney Function in Diabetic Patients .
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Date
2011
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Abstract
Serum cystatin C is a new promising marker of renal function. The aim of this study was to
analyze serum cystatin C as a better predictor of renal function in diabetic nephropathy. In
60 diagnosed diabetic patients, serum cystatin C and serum creatinine were assessed.
Glomerular filtration rate was estimated based on the cystatin C concentration according to
Cockcroft- Gault formula and based on serum creatinine concentration according to Larsson
formula. DTPA-GFR (Diethylenetriamene pentaacetate Renogram) was done as reference
standard. The cross tabulation of DTPA-GFR was done with eGFR- creatinine and eGFRcystatin
C. The calculated sensitivity, specificity and accuracy of eGFR- creatinine were
85%, 87.2% and 85% respectively. The eGFR- cystatin C showed higher sensitivity,
specificity and accuracy than eGFR- creatinine in studied diabetic subjects. The cystatin C
showed more significant correlation, r=0.78, p<0.001 than serum creatinine, r=0.59,
p<0.001 with DTPA-GFR in diabetic patients. This study demonstrates that serum cystatin
C may be used for early prediction for renal function impairment in diabetic kidney disease.
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Keywords
Cystatin C, DTPA-GFR, eGFR-creatinine, eGFR-Cystatin C, Abreviation, eGFR- Estimated Glomerular Filtration Rate
Citation
Shima T S, Khatun A, Yeasmin F, Ferdousi S , Kirtania K, Sultana N. Cystatin C: A Better Predictor of Kidney Function in Diabetic Patients . Bangladesh Journal of Medical Biochemistry. 2011; 4(1): 16-20.