Behavioural and neuroendocrine effects of aqueous extract of Boerhaavia diffusa Linn. in mice using tail suspension and forced swim tests – A preliminary study.

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dc.contributor.authorDhingra, Dinesh
dc.contributor.authorValecha, Rekha
dc.date.accessioned2014-04-29T09:40:16Z
dc.date.available2014-04-29T09:40:16Z
dc.date.issued2014-01
dc.description.abstractThe present study was done to evaluate the effect of aqueous extract of B. diffusa on depression in mice using behavioral models such as tail suspension test (TST) and forced swim test (FST). The extract (50, 100 and 200 mg/kg, po) was administered for 14 successive days to Swiss young albino mice. On 14th day, 60 min after administration, mice were subjected to TST and FST. The administration of aqueous extract of B. diffusa (50, 100 and 200 mg/kg, po) significantly decreased immobility period in both TST and FST, indicating significant antidepressant-like activity. The lowest dose (50 mg/kg) of the extract decreased the immobility period most significantly in FST, showing most potent antidepressant-like action. The efficacy of the extract (50 mg/kg) was comparable to fluoxetine (20 mg/kg). The extract did not show any significant effect on locomotor activity. The extract showed significant monoamine oxidase -A inhibitory activity. There was no significant effect of the extract on plasma corticosterone levels. Prazosin (α1-adrenoceptor antagonist), sulpiride (selective D2-receptor antagonist), baclofen (GABAB agonist), and p-CPA (tryptophan hydroxylase inhibitor) significantly attenuated the extract-induced antidepressant-like effect, when tested in TST. The extract might produce antidepressant-like effect by interaction with α1-adrenoceptors, dopamine-D2 receptors, serotonergic, and GABAB receptors. Thus, aqueous extract of B. diffusa showed significant antidepressant-like activity in mice probably through involvement of monoaminergic and GABAergic systems.en_US
dc.identifier.citationDhingra Dinesh, Valecha Rekha. Behavioural and neuroendocrine effects of aqueous extract of Boerhaavia diffusa Linn. in mice using tail suspension and forced swim tests – A preliminary study. Indian Journal of Experimental Biology. 2014 Jan; 52(1): 53-59.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/150332
dc.language.isoenen_US
dc.source.urihttps://nopr.niscair.res.in/handle/123456789/25159en_US
dc.subjectBoerhaavia diffusaen_US
dc.subjectDepressionen_US
dc.subjectForced swim testen_US
dc.subjectMonoamine oxidaseen_US
dc.subjectTail suspension testen_US
dc.subject.meshAnimals
dc.subject.meshAntidepressive Agents --administration & dosage
dc.subject.meshDepression --drug therapy
dc.subject.meshDepression --pathology
dc.subject.meshFluoxetine --administration & dosage
dc.subject.meshHindlimb Suspension --physiology
dc.subject.meshMale
dc.subject.meshMice
dc.subject.meshMonoamine Oxidase --drug effects
dc.subject.meshNyctaginaceae --chemistry
dc.subject.meshPhysical Exertion --drug effects
dc.subject.meshPlant Extracts --administration & dosage
dc.subject.meshPlant Extracts --chemistry
dc.titleBehavioural and neuroendocrine effects of aqueous extract of Boerhaavia diffusa Linn. in mice using tail suspension and forced swim tests – A preliminary study.en_US
dc.typeArticleen_US
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