Efficacy Of Binary Combination Of Deltamethrin+Mgk-264 On Levels Of Biochemical Changes In The Snail Lymnaea Acuminata

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dc.contributor.authorSingh, R. N.en_US
dc.contributor.authorKumar, P.en_US
dc.contributor.authorKumar, N.en_US
dc.contributor.authorSingh, D. K.en_US
dc.date.accessioned2020-09-24T08:01:42Z
dc.date.available2020-09-24T08:01:42Z
dc.date.issued2020-08
dc.description.abstractObjective: The objective of the present study is the evaluation of the effect of the sublethal (40% and 60% of 48h LC50) binary combination (1:5 ratios) of molluscicides deltamethrin+MGK-264 on the endogenous levels of protein, amino acid and nucleic acid in different tissues of snail Lymnaea acuminata. Methods: The snails were treated with 1:5 mixtures of sub-lethal concentration of (40% and 60% of 48h LC50) deltamethrin+MGK-264 on the protein, amino acid and nucleic acid levels in gonadal, nervous and foot tissue of L. acuminata. In order to study the effect of withdrawal from treatment, the snails were first exposed to the above concentrations for 96h, after which they were transferred to freshwater. Water was changed every 24h for the next seven days, after which different biochemical parameters were estimated. Results: There was a significant change in the levels of protein (sublethal concentration of 60% of 48h LC50 after 96h) gonadal, nervous and foot tissues are 48.1, 12.1 and 14.5%, respectively, amino acid are 273, 234 and 252%, respectively, DNA are 25.1, 38.9 and 42.1%, respectively and RNA are 12.2, 30.7 and 30.5%, respectively. These changes were time and concentration-dependent. In the withdrawal experiment, the snails were treated for 96h to transfer in freshwater for 7 d, which caused significant recovery in all the biochemical parameters. Conclusion: The present study concluded that the high molluscicidal activity of deltamethrin+MGK-264 simultaneous decrease in the levels of proteins, DNA, RNA and increase in the level of amino acids.en_US
dc.identifier.affiliationsDepartment of Zoology, Maharana Pratap P. G. College Jungle Dhusan, Gorakhpur (U. P)en_US
dc.identifier.affiliationsDepartment of Zoology, S. G. N. Govt. P. G. College Muhammadabad Gohna Mau, (U. P)en_US
dc.identifier.affiliationsDepartment of Zoology, Maharana Pratap P. G. College Jungle Dhusan, Gorakhpur (U. P)en_US
dc.identifier.affiliationsDepartment of Zoology, D. D. U Gorakhpur University Gorakhpur, (U. P)en_US
dc.identifier.citationSingh R. N., Kumar P., Kumar N., Singh D. K.. Efficacy Of Binary Combination Of Deltamethrin+Mgk-264 On Levels Of Biochemical Changes In The Snail Lymnaea Acuminata. International Journal of Pharmacy and Pharmaceutical Sciences. 2020 Aug; 12(8): 111-116en_US
dc.identifier.issn0975-1491
dc.identifier.issn2656-0097
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/206006
dc.languageenen_US
dc.publisherInnovare Academic Sciences Pvt. Ltd.en_US
dc.relation.issuenumber8en_US
dc.relation.volume12en_US
dc.source.urihttps://doi.org/10.22159/ijpps.2020v12i8.38402en_US
dc.subjectFasciolosisen_US
dc.subjectDeltamethrin MGK-264en_US
dc.subjectProteinen_US
dc.subjectAmino aciden_US
dc.subjectNucleic aciden_US
dc.subjectLymnaea acuminataen_US
dc.titleEfficacy Of Binary Combination Of Deltamethrin+Mgk-264 On Levels Of Biochemical Changes In The Snail Lymnaea Acuminataen_US
dc.typeJournal Articleen_US
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