Ellagic acid modulates sodium valproate induced reproductive toxicity in male Wistar rats.

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dc.contributor.authorGirish, Chandrashekaran
dc.contributor.authorShweta, Oommen
dc.contributor.authorRaj, Vishnu
dc.contributor.authorBalakrishnan, Sadasivam
dc.contributor.authorG’boy Varghese, Renu
dc.date.accessioned2015-02-21T07:47:44Z
dc.date.available2015-02-21T07:47:44Z
dc.date.issued2014-10
dc.description.abstractThis study evaluated the protective effect of ellagic acid on sodium valproate-induced sperm abnormalities in male Wistar rats. A total of 30 rats were grouped into five groups, each having 6 animals. Vehicle, sodium valproate (400 mg/kg) and ellagic acid (10, 25, 50 mg/kg) were given orally from day 1 to day 7, and ellagic acid was continued for 3 more days. On day fourteen, animals were sacrificed and the different parameters were recorded. There was a significant decrease in the sperm count and sperm motility after the exposure to sodium valproate. The percentage of abnormal sperms increased in a dose-dependent manner. The histopathological examination revealed that sodium valproate had caused degeneration and desquamation of germinal cells in the epithelium and also showed a decrease in the Johnsen’s scoring. Ellagic acid provided partial protection at the doses of 10 and 25 mg/kg and complete protection at 50 mg/kg, against sodium valproate induced testicular and spermatozoal damage.en_US
dc.identifier.citationGirish Chandrashekaran, Shweta Oommen, Raj Vishnu, Balakrishnan Sadasivam, G’boy Varghese Renu. Ellagic acid modulates sodium valproate induced reproductive toxicity in male Wistar rats. Indian Journal of Physiology and Pharmacology. 2014 Oct-Dec ; 58 (4) : 416-422.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/156232
dc.language.isoenen_US
dc.source.urihttps://www.ijpp.com/IJPP%20archives/2014_58_4/416-422.pdfen_US
dc.titleEllagic acid modulates sodium valproate induced reproductive toxicity in male Wistar rats.en_US
dc.typeArticleen_US
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