Ellagic acid modulates sodium valproate induced reproductive toxicity in male Wistar rats.
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Date
2014-10
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Abstract
This study evaluated the protective effect of ellagic acid on sodium valproate-induced sperm abnormalities
in male Wistar rats. A total of 30 rats were grouped into five groups, each having 6 animals. Vehicle, sodium
valproate (400 mg/kg) and ellagic acid (10, 25, 50 mg/kg) were given orally from day 1 to day 7, and ellagic
acid was continued for 3 more days. On day fourteen, animals were sacrificed and the different parameters
were recorded. There was a significant decrease in the sperm count and sperm motility after the exposure
to sodium valproate. The percentage of abnormal sperms increased in a dose-dependent manner. The histopathological
examination revealed that sodium valproate had caused degeneration and desquamation of
germinal cells in the epithelium and also showed a decrease in the Johnsen’s scoring. Ellagic acid provided
partial protection at the doses of 10 and 25 mg/kg and complete protection at 50 mg/kg, against sodium
valproate induced testicular and spermatozoal damage.
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Girish Chandrashekaran, Shweta Oommen, Raj Vishnu, Balakrishnan Sadasivam, G’boy Varghese Renu. Ellagic acid modulates sodium valproate induced reproductive toxicity in male Wistar rats. Indian Journal of Physiology and Pharmacology. 2014 Oct-Dec ; 58 (4) : 416-422.