Effects of Diet and Exercise in Middle Aged Subjects with Impaired Glucose Tolerance.
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Date
2014
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Abstract
Patients with impaired glucose tolerance (IGT) are now considered as being pre-diabetic,
which indicates their relatively high risk for developing diabetes mellitus associated with
abnormal metabolic syndrome and cardiovascular diseases. However, dietary modification
and physical exercise may play a critical role in this respect. To determine the influence of
dietary modification and physical exercise in subjects with impaired glucose tolerance in
Bangladesh, thirty three newly detected otherwise healthy subjects with IGT, aged 30-63
years, were randomly selected to participate in a 12 weeks diet and exercise program.
Substantial improvement in glucose tolerance was observed at the end of 12 weeks
particularly in middle aged subjects (41-50 years). Mean fasting blood glucose and 2 hr post
load glucose value were reduced significantly. Glucose tolerance was reverted to normal in
66.7% of the participants, remained unchanged in 26.7% and deteriorated to diabetes in
6.7%. Significant reduction in serum total cholesterol, LDL cholesterol along with mild
deterioration in HDL cholesterol and increase in triglyceride values were observed. It was
found that the principles of 'prudent diet' in combination with physical exercise are highly
effective in improving glucose tolerance, lowering total cholesterol and LDL cholesterol in
IGT subjects.
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Keywords
Impaired Glucose Tolerance, Prudent Diet, Physical Exercise, Blood Glucose Regulation, T2DM
Citation
Haque M M, Shahjahan M, Haque M S, Absar N. Effects of Diet and Exercise in Middle Aged Subjects with Impaired Glucose Tolerance. Bangladesh Journal of Medical Biochemistry. 2014; 7(1): 17-26.