Genetic Aberrations in Caspase Family of Genes and Their Possible Association with HNSCC

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dc.contributor.authorNirubama, K.en_US
dc.contributor.authorGirija, A. S. Smilineen_US
dc.contributor.authorParamasivam, A.en_US
dc.contributor.authorPriyadharsini, J. Vijayashreeen_US
dc.date.accessioned2020-11-18T10:30:18Z
dc.date.available2020-11-18T10:30:18Z
dc.date.issued2020-08
dc.description.abstractThe cell suicide pathway of apoptosis is a necessary event in the life of multicellular organisms. It is involved in many biological processes ranging from development to the immune response. Over expression of interleukin-1β-converting enzyme (later renamed caspase-1) was shown to be sufficient to induce apoptosis in mammalian cells. The present study aims to assess the gene alterations in the Caspase family of cytochromes so as to derive an association with HNSCC. Earlier eleven genes were found in the human genome to encode 11 human caspases, caspase-1 to caspase-10 and caspase-14, which is now populated to 13, whereas 10 genes were found in the mouse genome to encode 10 murine caspases including caspase-1, 2, 3, 6, 7, 8, 9, 11, 12 and 14 Caspases share a number of features distinguishable from other proteases. The analysis follows an observational study design, employing several computational tools to identify and predict the possible outcomes of gene alterations identified in HNSCC patients. cBioportal server was used to identify the gene alterations which was further analyzed using tools such as PROVEAN, I-Mutant and gnomAD. Several reported polymorphic variants were also identified. The pathogenicity and protein stability of gene alterations documented in the present study were identified at standard biological conditions. Further experimental studies would provide concrete evidence on the association of the observed genetic abnormalities with HNSCC especially in individuals exposed to habitual carcinogensen_US
dc.identifier.affiliationsSaveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai-600077, India.en_US
dc.identifier.affiliationsDepartment of Microbiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai-600077, Indiaen_US
dc.identifier.affiliationsBiomedical Research Unit and Laboratory Animal Centre-Dental Research Cell, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai 600077, Indiaen_US
dc.identifier.citationNirubama K., Girija A. S. Smiline, Paramasivam A., Priyadharsini J. Vijayashree. Genetic Aberrations in Caspase Family of Genes and Their Possible Association with HNSCC. Journal of Pharmaceutical Research International. 2020 Aug; 32(15): 83-95en_US
dc.identifier.issn2456-9119
dc.identifier.issn2231-2919
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/215877
dc.languageenen_US
dc.publisherSCIENCEDOMAIN internationalen_US
dc.relation.issuenumber15en_US
dc.relation.volume32en_US
dc.source.urihttps://doi.org/10.9734/JPRI/2020/v32i1530629en_US
dc.subjectCaspase family geneen_US
dc.subjectHNSCCen_US
dc.subjectin silicoen_US
dc.subjectmutationsen_US
dc.subjectamplificationen_US
dc.subjectdeletionsen_US
dc.titleGenetic Aberrations in Caspase Family of Genes and Their Possible Association with HNSCCen_US
dc.typeJournal Articleen_US
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