Neoadjuvant chemotherapy for invasive squamous cell carcinoma of the conjunctiva: A case report.

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dc.contributor.authorNair, Akshay Gopinathan
dc.contributor.authorKaliki, Swathi
dc.contributor.authorMishra, Dilip Kumar
dc.contributor.authorReddy, Vijay Anand
dc.contributor.authorNaik, Milind N
dc.date.accessioned2016-11-30T05:11:48Z
dc.date.available2016-11-30T05:11:48Z
dc.date.issued2015-12
dc.description.abstractA 40‑year‑old male presented with an orbital extension of conjunctival squamous cell carcinoma (SCC). The orbital mass was seen protruding outward from the left palpebral fissure overhanging the lower eyelid, completely obscuring the globe and lower lid. The patient gave a history of excision biopsy, which was histopathologically diagnosed as ocular surface squamous neoplasia. He also gave a history of tumor recurrence, which gradually progressed to assume the form of the presently visible orbital mass. Computed tomography of the orbits showed the mass extending into the left orbit causing superior displacement of the globe. After a negative locoregional and systemic metastatic screening, neoadjuvant intravenous systemic chemotherapy with cisplatin and 5‑fluorouracil were initiated in an attempt to reduce the size of the tumor. Three cycles of tri‑weekly chemotherapy resulted in a significant reduction of the orbital tumor size with the globe and the lower lid being visible, thus making a lid‑sparing orbital exenteration possible. The patient subsequently underwent an orbital exenteration and at 6‑month follow‑up, the patient was free from local and regional disease. To our knowledge, this is the first reported case where systemic neoadjuvant chemotherapy has been used to reduce the size of invasive SCC with orbital extension, thereby permitting a lid‑sparing orbital exenteration.en_US
dc.identifier.citationNair Akshay Gopinathan, Kaliki Swathi, Mishra Dilip Kumar, Reddy Vijay Anand, Naik Milind N. Neoadjuvant chemotherapy for invasive squamous cell carcinoma of the conjunctiva: A case report. Indian Journal of Ophthalmology. 2015 Dec; 63(12): 927-929.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/179062
dc.language.isoenen_US
dc.source.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4784084/en_US
dc.subjectChemotherapyen_US
dc.subjectconjunctivaen_US
dc.subjectexenterationen_US
dc.subjecteyeen_US
dc.subjectneoadjuvanten_US
dc.subjectocular surface squamous neoplasiaen_US
dc.subjectsquamous cell carcinomaen_US
dc.subjecttumoren_US
dc.titleNeoadjuvant chemotherapy for invasive squamous cell carcinoma of the conjunctiva: A case report.en_US
dc.typeArticleen_US
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