Neoadjuvant chemotherapy for invasive squamous cell carcinoma of the conjunctiva: A case report.
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Date
2015-12
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Abstract
A 40‑year‑old male presented with an orbital extension of
conjunctival squamous cell carcinoma (SCC). The orbital mass
was seen protruding outward from the left palpebral fissure
overhanging the lower eyelid, completely obscuring the globe
and lower lid. The patient gave a history of excision biopsy,
which was histopathologically diagnosed as ocular surface
squamous neoplasia. He also gave a history of tumor recurrence,
which gradually progressed to assume the form of the presently
visible orbital mass. Computed tomography of the orbits
showed the mass extending into the left orbit causing superior
displacement of the globe. After a negative locoregional and
systemic metastatic screening, neoadjuvant intravenous systemic
chemotherapy with cisplatin and 5‑fluorouracil were initiated
in an attempt to reduce the size of the tumor. Three cycles of
tri‑weekly chemotherapy resulted in a significant reduction of the
orbital tumor size with the globe and the lower lid being visible,
thus making a lid‑sparing orbital exenteration possible. The
patient subsequently underwent an orbital exenteration and at
6‑month follow‑up, the patient was free from local and regional
disease. To our knowledge, this is the first reported case where
systemic neoadjuvant chemotherapy has been used to reduce the
size of invasive SCC with orbital extension, thereby permitting a
lid‑sparing orbital exenteration.
Description
Keywords
Chemotherapy, conjunctiva, exenteration, eye, neoadjuvant, ocular surface squamous neoplasia, squamous cell carcinoma, tumor
Citation
Nair Akshay Gopinathan, Kaliki Swathi, Mishra Dilip Kumar, Reddy Vijay Anand, Naik Milind N. Neoadjuvant chemotherapy for invasive squamous cell carcinoma of the conjunctiva: A case report. Indian Journal of Ophthalmology. 2015 Dec; 63(12): 927-929.