ANTIDEPRESSANT-LIKE ACTIVITY OF METHANOLIC EXTRACT OF WITHANIA QARAITICA IN MICE

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dc.contributor.authorALMAQBALI, REEM KHALFANen_US
dc.contributor.authorSHAIKH, JAMALUDDINen_US
dc.contributor.authorWELI, AFAF MOHAMMEDen_US
dc.contributor.authorSAID, SADRI ABDULLAHen_US
dc.date.accessioned2024-09-24T08:25:03Z
dc.date.available2024-09-24T08:25:03Z
dc.date.issued2023-02
dc.description.abstractObjective: The goal of the present study was to assess the antidepressant-like action of Withania qaraitica in two behavioral animal models, the forced-swimming test (FST) and tail suspension test (TST) in mice.Methods: Withania qaraitica methanolic extract was prepared by the maceration. The antidepressant activity was measured by the forced-swimming test (FST) using C57BL/6 mice and the tail suspension test (TST) using BALB/c mice. Mice were divided into three groups: control (DMSO), standard (citalopram and desipramine), and Withania qaraitica methanolic extract (n = 6 per group). Drugs were injected (1 ml/100 g) intraperitoneally (i. p.). Data were evaluated using analysis of variance, followed by LSD post-hoc tests, where *p<0.001 was considered significantly different from the vehicle control. The data are expressed as meanĀ±SEM.Results: In both the FST and the TST, antidepressant-positive controls citalopram and desipramine significantly reduced the time of immobility compared to vehicle control (p<0.001). The methanolic extract of Withania qaraitica at the dose of 40 mg/kg significantly reduced the immobility times with respect to vehicle control as well as lower doses of the same extract (10 and 20 mg/kg) in FST (p<0.001). In a similar fashion, the methanolic extract of Withania qaraitica at the dose of 40 mg/kg significantly decreased the duration of immobility in TST (p<0.005).Conclusion: The current results show the antidepressant-like activity of Withania qaraitica in mice. This observation warrants additional studies to identify the underlining mechanism by which Withania qaraitica produces antidepressant-like effects.en_US
dc.identifier.affiliationsSchool of Pharmacy, College of Pharmacy and Nursing, University of Nizwa, Sultanate of Omanen_US
dc.identifier.affiliationsSchool of Pharmacy, College of Pharmacy and Nursing, University of Nizwa, Sultanate of Omanen_US
dc.identifier.affiliationsSchool of Pharmacy, College of Pharmacy and Nursing, University of Nizwa, Sultanate of Omanen_US
dc.identifier.affiliationsSchool of Pharmacy, College of Pharmacy and Nursing, University of Nizwa, Sultanate of Omanen_US
dc.identifier.citationALMAQBALI REEM KHALFAN, SHAIKH JAMALUDDIN, WELI AFAF MOHAMMED, SAID SADRI ABDULLAH . ANTIDEPRESSANT-LIKE ACTIVITY OF METHANOLIC EXTRACT OF WITHANIA QARAITICA IN MICE . International Journal of Pharmacy and Pharmaceutical Sciences . 2023 Feb; 15(2): 25-30en_US
dc.identifier.issn0975-1491
dc.identifier.issn2656-0097
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/231170
dc.languageenen_US
dc.publisherInnovare Academic Sciences Pvt. Ltd.en_US
dc.relation.issuenumber2en_US
dc.relation.volume15en_US
dc.source.urihttps://doi.org/10.22159/ijpps.2023v15i2.46788en_US
dc.subjectWithania qaraiticaen_US
dc.subjectCitalopramen_US
dc.subjectDesipramineen_US
dc.subjectAntidepressant-like effecten_US
dc.subjectForced-swimming testen_US
dc.subjectTail suspension testen_US
dc.titleANTIDEPRESSANT-LIKE ACTIVITY OF METHANOLIC EXTRACT OF WITHANIA QARAITICA IN MICEen_US
dc.typeJournal Articleen_US
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