Expanded Indian National Rotavirus Surveillance Network in the Context of Rotavirus Vaccine Introduction.
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Date
2016-07
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Abstract
Objective: To extend a nation-wide rotavirus surveillance network in India, and to generate geographically representative data on rotaviral disease burden and prevalent strains.
Design: Hospital-based surveillance.
Setting: A comprehensive multicenter, multi-state hospital based surveillance network was established in a phased manner involving 28 hospital sites across 17 states and two union territories in India.
Patients: Cases of acute diarrhea among children below 5 years of age admitted in the participating hospitals.
Results: During the 28-month study period between September 2012 and December 2014, 11898 children were enrolled and stool samples from 10207 children admitted with acute diarrhea were tested; 39.6% were positive for rotavirus. Highest positivity was seen in Tanda (60.4%) and Bhubaneswar (60.4%) followed by Midnapore (59.5%). Rotavirus infection was seen more among children aged below 2 years with highest (46.7%) positivity in the age group of 12-23 months. Cooler months of September – February accounted for most of the rotavirus-associated gastroenteritis, with highest prevalence seen during December – February (56.4%). 64% of rotavirus-infected children had severe to very severe disease. G1 P[8] was the predominant rotavirus strain (62.7%) during the surveillance period.
Conclusions: The surveillance data highlights the high rotaviral disease burden in India. The network will continue to be a platform for monitoring the impact of the vaccine.
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Keywords
Epidemiology, Rotavirus diarrhea, Vaccine
Citation
Sanjay Mehendale, S Venkatasubramanian, CP Girish Kumar, Gagandeep Kang, MD Gupte and Rashmi Arora. Expanded Indian National Rotavirus Surveillance Network in the Context of Rotavirus Vaccine Introduction.