Diagnosis of Hyperparathiroidism after Surgical Treatment of OsteolyticLesion
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Date
2018-09
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Society for Health Care & Research Development
Abstract
Several metabolic diseases can affect normal process of osteogenesis, involving the formation of a collagen matrix, where the salts that form the bone are deposited. The homeostasis of calcium and phosphate metabolism is regulated by the activity of the parathyroid glands, whose alterations are associated with bone modifications. Parathyroid hormone (PTH) exerts profound effects on skeletal homeostasis through several cellular and molecular mechanisms. Chronic hyperparathyroidism causes net loss of bone mass, despite accelerating bone formation by osteoblasts. An increased secretion of PTH, caused for example by an adenoma of the parathyroid glands, can induce the formation of a central giant cellular lesion of the jaws known as Brown’s Tumour of the jaws, that may lead to evident osteolysis and gross deformity in the maxillofacial region. This may be the first presentation of this disease. The authors report a 79-years-old male patient who presented with an asymptomatic osteolytic lesion in the right maxilla as the first manifestation of primary hyperparathyroidism, caused by a parathyroid adenoma. The authors describe the surgical treatment of the maxillary lesion, the procedure that led to the diagnosis of hyperparathyroidism and its treatment.
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Agnone A, Ciccarelli E, Giordano Lu, Abbona G, Saracco R. Non-Surgical Periodontal Therapy- A Noteworthy Contribution towards Oral Health. Annals of International medical and Dental Research. 2018 Sep; 4(5): 8-11