An In-Depth Review on Recent Developments in Oral Ketoprofen Delivery: Strategies for Enhanced Therapeutic Performance

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dc.contributor.authorElballa, Wen_US
dc.contributor.authorSalih, Men_US
dc.contributor.authorElawni, AE.en_US
dc.date.accessioned2025-05-12T10:23:18Z
dc.date.available2025-05-12T10:23:18Z
dc.date.issued2024-12
dc.description.abstractKetoprofen, a widely prescribed non-steroidal anti-inflammatory drug (NSAID), suffers from limited oral bioavailability due to poor solubility and a short half-life, leading to frequent dosing and potential gastric irritation. This review examines recent advancements in oral Ketoprofen delivery, reporting clear findings in bioavailability improvement and gastric protection. Controlled-release systems—such as Zn-alginate beads, polysaccharide hydrogels, and monolithic osmotic tablets—demonstrated sustained drug release with reduced gastric side effects, extending anti-inflammatory action up to 7 hours. Oral-dissolving formulations, including fast-disintegrating tablets and electrospun fibers, showed enhanced dissolution rates and improved patient compliance, particularly benefiting individuals with swallowing difficulties. Complexation with polymers (e.g., polyacrylamide-grafted gum and sodium alginate) created pH-sensitive microbeads that released 83% of Ketoprofen at neutral pH, supporting gastro-protective effects. Lipid-based formulations, such as nanostructured lipid carriers and self-emulsifying systems, effectively improved solubility and permeability, enhancing Ketoprofen’s absorption by up to 2.4 times. These findings underscore the potential of tailored delivery systems in optimizing Ketoprofen's therapeutic efficacy, safety, and patient adherence.en_US
dc.identifier.affiliationsThe Biopharmaceutical Innovation and Optimization Center, Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, Kansas, USAen_US
dc.identifier.affiliationsDepartment of Pharmaceutics, Faculty of Pharmacy, Sudan University of Science and Technology, Khartoum, Sudan and Department of Research and Development, Pharmaceutical Solutions Industry Ltd, Jeddah, Saudi Arabiaen_US
dc.identifier.affiliationsDepartment of Production, Klybeck Life Sciences SA, Dammam, Saudi Arabia.en_US
dc.identifier.citationElballa W, Salih M, Elawni AE.. An In-Depth Review on Recent Developments in Oral Ketoprofen Delivery: Strategies for Enhanced Therapeutic Performance . Journal of Pharmaceutical Research International. 2024 Dec; 36(12): 78-93en_US
dc.identifier.issn2456-9119
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/247692
dc.languageenen_US
dc.publisherMs. M. B. Mondalen_US
dc.relation.issuenumber12en_US
dc.relation.volume36en_US
dc.source.urihttps://doi.org/10.9734/jpri/2024/v36i127630en_US
dc.subjectOral Ketoprofenen_US
dc.subjectNsaiden_US
dc.subjecttherapeutic performanceen_US
dc.subjectpatients diagnoseden_US
dc.titleAn In-Depth Review on Recent Developments in Oral Ketoprofen Delivery: Strategies for Enhanced Therapeutic Performanceen_US
dc.typeJournal Articleen_US
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