Changes in Serum Immunoglobulin Levels Among Cynomolgus Monkeys with Long Term Morphine Treatment

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dc.contributor.authorWannapa Ishidaen_US
dc.contributor.authorSuchinda Malaivijitnonden_US
dc.contributor.authorTakafumi Ishidaen_US
dc.date.accessioned2011-02-24T04:34:31Z
dc.date.available2011-02-24T04:34:31Z
dc.date.created2010-05-28en_US
dc.date.issued2010-05-28en_US
dc.description.abstract Effects of chronic morphine exposure to monkeys on humoral immune status with reference to serum cortisol levels were studied.  Male cynomolgus monkeys (Macaca fascicularis) were exposed to morphine daily (3mg/kg; n=3, 6mg/kg; n=3) and their blood spfecimens were collected every week to test serum levels of immunoglobulins and cortisol. Serum cortisol levels decreased initially and then elevated gradually.  Levels of immunoglobulins, IgG and IgM, in monkeys exposed to large dose (6mg/kg) of morphine was lower than that in monkeys with small dose (3mg/kg).  An elevation in Igs levels were obsereved in monkeys treated with the small dose of morphine but consistent reduction in the serum IgG levels was observed in monkeys exposed to morphine with the large dose.  Therefore, chronic exposure to the large dose of morphine may lead to immunosuppression and result in disease prone status. en_US
dc.identifier.citationSrinagarind Medical Journal (SMJ); Vo. 11 No. 2 April - June 1996; 57-63en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/134012
dc.language.isoen_USen_US
dc.publisherFaculty of Medicine, Khon Kaen Universityen_US
dc.rightsAcademic Affairs, Faculty of Medicine, Khon Kaen University, KhonKaen, Thailanden_US
dc.source.urihttps://thailand.digitaljournals.org/index.php/SMJ/issue/archiveen_US
dc.source.urihttps://thailand.digitaljournals.org/index.php/SMJ/article/view/4117en_US
dc.titleChanges in Serum Immunoglobulin Levels Among Cynomolgus Monkeys with Long Term Morphine Treatmenten_US
dc.typeOriginal Articlesen_US
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