Mixed Medullary and Papillary Carcinoma Thyroid in a Young Female- A Rare Case Report

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dc.contributor.authorSiddiqui, Bushraen_US
dc.contributor.authorKhan, Roobinaen_US
dc.contributor.authorNasreen, Tausiaen_US
dc.contributor.authorFaridi, Shahbaz Habiben_US
dc.contributor.authorHarris, S Hasanen_US
dc.contributor.authorAhmed, S Shamshaden_US
dc.date.accessioned2019-11-16T07:26:24Z
dc.date.available2019-11-16T07:26:24Z
dc.date.issued2015-10
dc.description.abstractThe medullary thyroid carcinomas (MTC) comprise 5-10% of all thyroid carcinomas. It is known to show many cyto-architectural variations. The WHO classification of thyroid tumors includes an entity called mixed medullary-papillary carcinoma, a rare malignancy known to represent <1% of all thyroid malignancies. Fewer than 40 such cases have been reported so far and include tumors showing morphological features of both medullary carcinoma and papillary carcinoma with immunoreactivity for calcitonin and CK19 &thyroglobulin respectively. We report a case of a 27-year-old female with complaints of gradually increasing neck swelling for 2 years, with difficulty in swallowing in the last 2 months. The swelling was more localized towards left. Ultrasound neck revealed a nodule in the left lobe of thyroid with benign features most likely nodular colloid goiter. Thyroid profile of the patient was normal. FNA revealed sheets and follicles lined by both hyperplastic and involutional follicular cells. Few micro follicles showed pleomorphic cells having hyperchromatic nuclei and mild anisonucleosis. A diagnosis of colloid goiter was given on cytology; however, on grounds of suspicion of a neoplastic process, histopathology was advised. The patient underwent total thyroidectomy. Hematoxylin & Eosin stained sections showed features of mixed medullary-papillary carcinoma of the thyroid which was further confirmed on Immunohistochemistry and raised serum calcitonin levels. It is important to know about this entity due to its prognostic implications, association with other endocrine disorders and to prevent any diagnostic dilemmas.en_US
dc.identifier.affiliationsDepartment of Pathology, JN Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Pathology, JN Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Pathology, JN Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Surgery, JN Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.en_US
dc.identifier.affiliationsDepartment of Surgery, JN Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.en_US
dc.identifier.affiliationsDepartment of Pathology, JN Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, Indiaen_US
dc.identifier.citationSiddiqui Bushra, Khan Roobina, Nasreen Tausia, Faridi Shahbaz Habib, Harris S Hasan, Ahmed S Shamshad. Mixed Medullary and Papillary Carcinoma Thyroid in a Young Female- A Rare Case Report. International Archives of BioMedical and Clinical Research. 2015 Oct-Dec; 1(2): 26-28en_US
dc.identifier.issn2454-9894
dc.identifier.issn2454-9886
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/184446
dc.languageenen_US
dc.publisherIbn Sina Academy of Medieval Medicine & Sciencesen_US
dc.relation.issuenumber2en_US
dc.relation.volume1en_US
dc.source.urihttps://doi.org/10.21276/iabcr.2015.1.2.7en_US
dc.subjectMedullary Thyroid Carcinomaen_US
dc.subjectThyroidectomyen_US
dc.subjectCarcinoma Thyroiden_US
dc.titleMixed Medullary and Papillary Carcinoma Thyroid in a Young Female- A Rare Case Reporten_US
dc.typeJournal Articleen_US
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