Effect of amaranth leaves on dimethylhydrazine-induced changes in multicomponent antioxidant system of rat liver.

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dc.contributor.authorAnilakumar, K Ren_US
dc.contributor.authorKhanum, Farhathen_US
dc.contributor.authorSudarshanakrishna, K Ren_US
dc.contributor.authorSanthanam, Ken_US
dc.date.accessioned2009-05-28T13:07:45Z
dc.date.available2009-05-28T13:07:45Z
dc.date.issued2004-06-21en_US
dc.description.abstractEffect of prefeeding dehydrated amaranth (A. gangeticus) leaves at 10 and 20% levels on a chemical toxicant, dimethylhydrazine (DMH)-induced free radical stress in rat liver was evaluated. DMH-induced rise in hepatic malondialdehyde (MDA), was diminished by AL. AL intake resulted in a significant increase in hepatic glutathione (GSH). The feeding of AL at 10% level increased the hepatic glucose-6-phosphate dehydrogenase (G-6-PDH) activity, while that at 20% level increased the hepatic glutathione reductase (GSSGR) as well, in addition to G-6-PDH. Amaranth leaves at 10 and 20% levels of feeding diminished the hepatic superoxide dismutase and glutathione peroxidase (GSH-Px) activities. DMH influenced adversely the hepatic antioxidant enzyme activities. Simultaneous administration of DMH and feeding of AL enhanced the DMH-induced decrease in hepatic GSH-Px. DMH enhanced formation of micronuclei was reverted significantly by AL intake. Hence, it was concluded that the consumption of AL at 20% level reduced DMH-induced impaired antioxidant status in rat liver.en_US
dc.description.affiliationBiochemistry and Nutrition Discipline, Defence Food Research Laboratory, Mysore 570 011, India. dfoodlab@sancharnet.inen_US
dc.identifier.citationAnilakumar KR, Khanum F, Sudarshanakrishna KR, Santhanam K. Effect of amaranth leaves on dimethylhydrazine-induced changes in multicomponent antioxidant system of rat liver. Indian Journal of Experimental Biology. 2004 Jun; 42(6): 595-600en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/59000
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAmaranthus --metabolismen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntioxidants --metabolismen_US
dc.subject.meshBody Weighten_US
dc.subject.meshBone Marrow --metabolismen_US
dc.subject.meshColon --metabolismen_US
dc.subject.meshDimethylhydrazines --pharmacologyen_US
dc.subject.meshFree Radicalsen_US
dc.subject.meshGlucosephosphate Dehydrogenase --metabolismen_US
dc.subject.meshGlutathione --metabolismen_US
dc.subject.meshGlutathione Peroxidase --metabolismen_US
dc.subject.meshGlutathione Reductase --metabolismen_US
dc.subject.meshLipid Peroxidationen_US
dc.subject.meshLiver --enzymologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMalondialdehyde --pharmacologyen_US
dc.subject.meshMicronuclei, Chromosome-Defective --metabolismen_US
dc.subject.meshOrgan Sizeen_US
dc.subject.meshOxidative Stressen_US
dc.subject.meshPlant Extracts --pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.subject.meshSuperoxide Dismutase --metabolismen_US
dc.titleEffect of amaranth leaves on dimethylhydrazine-induced changes in multicomponent antioxidant system of rat liver.en_US
dc.typeJournal Articleen_US
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