Hematological Changes in HCV Patients Treated with Different Sofosbuvir-Based Regimens

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dc.contributor.authorAhmed, Abdel Khaleken_US
dc.contributor.authorAbdel, Raouf El-Deiben_US
dc.contributor.authorGamal, Tawfiken_US
dc.contributor.authorSoliman, Nashaaten_US
dc.contributor.authorMosaad, Mohameden_US
dc.date.accessioned2020-10-16T08:45:02Z
dc.date.available2020-10-16T08:45:02Z
dc.date.issued2020-09
dc.description.abstractIntroduction: Treatment of HCV with direct acting antiviral agents (DAAs) with the different regimen dramatically changed the outcomes of the disease beside its eradication. In the same time hematological concerns as anemia, thrombocytopenia, and leucopenia were a major factor before initiation, or during treatment with the antiviral drugs.Aim: To demonstrate hematological changes during and after treatment with different regimen of DAAs.Methods: Follow up the hematological changes before, during and after treatment for 100 patients with chronic HCV treated with five different sofosbuvir-based regimen; using interferon, ribavirin, simeprevir and daclatasvir.Results: There are no similar linear changes regarding anemia, leucopenia or thrombocytopenia, however, combination therapy using sofosbuvir with simeprevir or daclatasvir significantly increase platelets count, WBCs, and hemoglobin level during and after end of treatment, versus regimens uses sofosbuvir with ribavirin and or interferon that showed significantly decreased hematological values during and after treatment.Conclusion:Sofosbuvir-based regimen has favorable hematological changes in patients with chronic HCV infection during and after treatments especially with sofosbuvir and daclatasviren_US
dc.identifier.affiliationsDepartment of Internal Medicine, Faculty of Medicine, Suez Canal University, Egypten_US
dc.identifier.affiliationsDepartment of Internal Medicine, Faculty of Medicine, Suez Canal University, Egypten_US
dc.identifier.affiliationsDepartment of Internal Medicine, Faculty of Medicine, Suez Canal University, Egypten_US
dc.identifier.affiliationsDepartment of Endemic and Infectious Diseases, Faculty of Medicine, Suez Canal University, Egypen_US
dc.identifier.affiliationsDepartment of Endemic and Infectious Diseases, Faculty of Medicine, Suez Canal University, Egypen_US
dc.identifier.citationAhmed Abdel Khalek, Abdel Raouf El-Deib, Gamal Tawfik, Soliman Nashaat, Mosaad Mohamed. Hematological Changes in HCV Patients Treated with Different Sofosbuvir-Based Regimens. International Journal of TROPICAL DISEASE & Health. 2020 Sep; 41(12): 10-17en_US
dc.identifier.issn2278–1005
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/209712
dc.languageenen_US
dc.publisherSCIENCEDOMAIN internationalen_US
dc.relation.issuenumber12en_US
dc.relation.volume41en_US
dc.source.urihttps://dx.doi.org//10.9734/IJTDH/2020/v41i1230337en_US
dc.subjectDAAsen_US
dc.subjectHCVen_US
dc.subjectHematological changesen_US
dc.titleHematological Changes in HCV Patients Treated with Different Sofosbuvir-Based Regimensen_US
dc.typeJournal Articleen_US
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