Effect of homeopathic medicines on transplanted tumors in mice.

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dc.contributor.authorEs, Sunilaen_US
dc.contributor.authorKuttan, Girijaen_US
dc.contributor.authorKc, Preethien_US
dc.contributor.authorKuttan, Ramadasanen_US
dc.date.accessioned2009-05-27T17:50:07Z
dc.date.available2009-05-27T17:50:07Z
dc.date.issued2007-07-28en_US
dc.descriptionAsian Pacific Journal of Cancer Prevention.en_US
dc.description.abstractUltra low doses used in homeopathic medicines are reported to have healing potential for various diseases but their action remains controversial. In this study we have investigated the antitumour and antimetastatic activity of selected homeopathic medicines against transplanted tumours in mice. It was found that Ruta graveolens 200c and Hydrastis canadensis 200c significantly increased the lifespan of Ehrlich Ascites Carcinoma and Dalton's Lymphoma Ascites induced tumour-bearing animals by 49.7%, and 69.4% respectively. Moreover there was 95.6% and 95.8% reduction of solid tumour volume in Ruta 200c and Hydrastis 200c treated animals on the 31st day after tumour inoculation. Hydrastis 1M given orally significantly inhibited the growth of developed solid tumours produced by DLA cells and increased the lifespan of tumour bearing animals. Some 9 out of 15 animals with developed tumors were completely tumour free after treatment with Hydrastis 1M. Significant anti-metastatic activity was also found in B16F-10 melanoma-bearing animals treated with Thuja1M, Hydrastis 1M and Lycopodium1M. This was evident from the inhibition of lung tumour nodule formation, morphological and histopathological analysis of lung and decreased levels of gamma-GT in serum, a cellular marker of proliferation. These findings support that homeopathic preparations of Ruta and Hydrastis have significant antitumour activity. The mechanism of action of these medicines is not known at present.en_US
dc.description.affiliationAmala Cancer Research Centre, Amala Nagar, Thrissur, Kerala State, India. 680555.en_US
dc.identifier.citationEs S, Kuttan G, Kc P, Kuttan R. Effect of homeopathic medicines on transplanted tumors in mice. Asian Pacific Journal of Cancer Prevention. 2007 Jul-Sep; 8(3): 390-4en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/37986
dc.language.isoengen_US
dc.source.urihttps://www.apocp.orgen_US
dc.subject.meshAnimalsen_US
dc.subject.meshHomeopathyen_US
dc.subject.meshHydrastisen_US
dc.subject.meshLycopodiumen_US
dc.subject.meshMelanoma --secondaryen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred C57BLen_US
dc.subject.meshMice, Inbred Strainsen_US
dc.subject.meshNeoplasm Metastasis --prevention & controlen_US
dc.subject.meshNeoplasms --drug therapyen_US
dc.subject.meshPlant Extracts --therapeutic useen_US
dc.subject.meshRutaen_US
dc.subject.meshThujaen_US
dc.titleEffect of homeopathic medicines on transplanted tumors in mice.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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