Ameliorative effect of Modified Atkins Diet against aluminium chloride induced cognitive, behavioural and neurochemical impairments in rats

Simple item page
dc.contributor.authorJangwan, Nitish Singhen_US
dc.contributor.authorSingh, Mamta Fen_US
dc.date.accessioned2025-06-18T11:43:09Z
dc.date.available2025-06-18T11:43:09Z
dc.date.issued2025-04
dc.description.abstractDietary and metabolic therapies are emerging Alzheimer's disease (AD) treatment contender due to paucity of effective therapeutic interventions. Modified Atkins Diet (MAD) is a less restrictive version of ketogenic diet and has higher compliance rate. Therefore, in the present study MAD treatment of different durations were investigated for their effect in Aluminium chloride induced AD in rats. Alzheimeric rats received MAD for a period of 4 weeks (treatment 1), 6 weeks (treatment 2) and 4 weeks of MAD + 2 weeks without any treatment (treatment 3). Treatment 2 showed significant decrease in escape latency in MWM while increase in working memory, discrimination ratio and locomotor activity in MWM, NORT and OFT respectively. All the treatments have a mild effect on body weight, body mass index and fasting blood sugar level. Treatment 2 significantly decreased total protein, calcium, lactate dehydrogenase and acetylcholinesterase level in alzheimeric rats. Treatment 2 also improved lipid profile and oxidative stress parameters when compared with toxicant control rats. Treatment 2 also improved brain cell histology in AD rats. Treatment 1 and treatment 3 caused moderate to slight improvement in animal models and biochemical study parameters in alzheimeric rats. Results of the study conclude that MAD treatment for 6 weeks significantly restored cognition, behavioural and neurochemical abnormalities of AD.en_US
dc.identifier.affiliationsDepartment of Pharmacognosy and Phytochemistry, School of Pharmaceutical Sciences, Delhi Pharmaceutical Sciences and Research University, New Delhi 110017, Indiaen_US
dc.identifier.affiliationsCollege of Pharmacy, COER University, Roorkee 247667, Uttarakhand, Indiaen_US
dc.identifier.citationJangwan Nitish Singh, Singh Mamta F . Ameliorative effect of Modified Atkins Diet against aluminium chloride induced cognitive, behavioural and neurochemical impairments in rats . Indian Journal of Experimental Biology. 2025 Apr; 63(4): 361-373en_US
dc.identifier.issn0019-5189
dc.identifier.issn0975-1009
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/249435
dc.languageenen_US
dc.publisherThe CSIR-National Institute of Science Communication and Policy Research (CSIR-NIScPR) (formerly known as NISCAIR).en_US
dc.relation.issuenumber4en_US
dc.relation.volume63en_US
dc.source.urihttps://doi.org/10.56042/ijeb.v63i04.14075en_US
dc.subjectAlzheimer's diseaseen_US
dc.subjectKetogenic dieten_US
dc.subjectKetosisen_US
dc.subjectNeurodegenerativeen_US
dc.subjectOxidative stressen_US
dc.titleAmeliorative effect of Modified Atkins Diet against aluminium chloride induced cognitive, behavioural and neurochemical impairments in ratsen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
ijeb2025v63n4p361.pdf
Size:
947.36 KB
Format:
Adobe Portable Document Format
Download
Collections
Indian Journal of Experimental Biology