Gene-environment Interactions and Polymorphism Studies of Cancer Risk in the Hospital-based Epidemiologic Research Program at Aichi Cancer Center II (HERPACC-II).

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dc.contributor.authorHamajima,en_US
dc.contributor.authorMatsuo,en_US
dc.contributor.authorSaito,en_US
dc.contributor.authorHirose,en_US
dc.contributor.authorInoue,en_US
dc.contributor.authorTakezaki,en_US
dc.contributor.authorKuroishi,en_US
dc.contributor.authorTajima,en_US
dc.date.accessioned2009-05-27T17:40:25Z
dc.date.available2009-05-27T17:40:25Z
dc.date.issued2001-01-30en_US
dc.descriptionAsian Pacific Journal of Cancer Prevention.en_US
dc.description.abstractGenetic polymorphisms may modify the effects of environmental risk factors on cancer occurrence. We have recently launched a comprehensive epidemiologic project, HERPACC II (Hospital-based Epidemiologic Research Program at Aichi Cancer Center II), including both lifestyle and polymorphism data, following HERPACC-I which solely concentrated on lifestyle data. As of April 2001, about 3000 samples of DNA are being stored to conduct case-control studies. Genotyping of 46 polymorphisms has been conducted at the laboratory of the Division of Epidemiology and Prevention. Twelve case-control studies and two papers on a new PCR method, PCR-CTPP (polymerase chain reaction with confronting two-pair primers), have been accepted for publication. Significant findings in Japanese were found for 1) gene-environment interaction for esophageal cancer between heavy drinking and aldehyde dehydrogenase 2 (ALDH2), 2) malignant lymphoma risk with methylenetetrahydrofalate reductase (MTHFR) and methionine synthase (MS), 3) interactions between smoking and two polymorphisms, interleukin 1B (IL-1B) and myeloperoxidase (MPO) for Helicobacter pylori infection, and 4) smoking habits with dopamine receptor D2 (DRD2) and IL-1B. Further studies on interactions with polymorphisms will continue to be conducted for Japanese, using larger sizes of samples.en_US
dc.description.affiliationDivision of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464-8681 Japan, nhamajim@aichi-cc.pref.aichi.jpen_US
dc.identifier.citationHamajima N, Matsuo K, Saito T, Hirose K, Inoue M, Takezaki T, Kuroishi T, Tajima K. Gene-environment Interactions and Polymorphism Studies of Cancer Risk in the Hospital-based Epidemiologic Research Program at Aichi Cancer Center II (HERPACC-II). Asian Pacific Journal of Cancer Prevention. 2001 ; 2(2): 99-107en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/37646
dc.language.isoENGen_US
dc.source.urihttps://www.apocp.orgen_US
dc.titleGene-environment Interactions and Polymorphism Studies of Cancer Risk in the Hospital-based Epidemiologic Research Program at Aichi Cancer Center II (HERPACC-II).en_US
dc.typeJOURNAL ARTICLEen_US
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