Correlation of glycated haemoglobin( HbA1c) with TNF-? and Oxidised-LDL in Type 2 DM

Simple item page
dc.contributor.authorPawar, Pen_US
dc.contributor.authorDhama, Aen_US
dc.contributor.authorChahal, Aen_US
dc.contributor.authorGhalaut, VS.en_US
dc.date.accessioned2025-05-14T09:32:52Z
dc.date.available2025-05-14T09:32:52Z
dc.date.issued2024-12
dc.description.abstractBackground: Type 2 diabetes mellitus (DM) is rising as a major health concern worldwide. The pathogenesis of DM and its complications involve an array of dynamic interactions between genes, inflammatory cytokines like TNF-?, oxidative stress, environmental factors, and lifestyle. Several studies have shown a strong correlation of Ox-LDL (Ox- idized low-density lipoprotein) and TNF-? (tumor necrosis factor-?) with IR (insulin resistance). Hence, the present study was designed to study the correlation between HbA1c (glycated hemoglobin) (a marker of glycemic control) with TNF-? (a marker of chronic inflammation) and Ox-LDL (a marker of oxidative stress). Aim and objectives: To study the correlation between TNF-? and Ox-LDL with HbA1c in Type 2 DM. Methods: For our pilot study, we recruited patients with type 2 DM belonging to the age group 35-50 years of either gender from Medicine OPD as cases. The institutional ethics committee approval has been taken before commence- ment of the study. After informed consent from patients, venous blood samples were collected and analyzed using a biochemistry autoanalyzer and appropriate ELISA kit. Data were analyzed statistically using SPSS software. Result: The study showed raised levels of HbA1c, TNF-?, and OX-LDL in type 2 DM patients. Conclusion: Furthermore, a significant positive correlation was observed between TNF-? and HbA1c (r = 0.829) and also between Ox-LDL and HbA1c (r = 0.638).en_US
dc.identifier.affiliationsDepartment of Biochemistry, NC Medical College and Hospital, Israna, Panipat, Haryana, 132107, Indiaen_US
dc.identifier.affiliationsDepartment of Biochemistry, NC Medical College and Hospital, Israna, Panipat, Haryana, 132107, Indiaen_US
dc.identifier.affiliationsDepartment of Biochemistry, Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, 124001, Indiaen_US
dc.identifier.affiliationsDepartment of Biochemistry, NC Medical College and Hospital, Israna, Panipat, Haryana, 132107, Indiaen_US
dc.identifier.citationPawar P, Dhama A, Chahal A, Ghalaut VS.. Correlation of glycated haemoglobin( HbA1c) with TNF-? and Oxidised-LDL in Type 2 DM . National Journal of Physiology, Pharmacy and Pharmacology. 2024 Dec; 14(12): 2607-2611en_US
dc.identifier.issn2231-3206
dc.identifier.issn2320-4672
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/247839
dc.languageenen_US
dc.publisher?Eldaghayes Publisheren_US
dc.relation.issuenumber12en_US
dc.relation.volume14en_US
dc.source.urihttps://doi.org/10.5455/NJPPP.2024.v14.i12.19en_US
dc.subjecttype 2 diabetes mellitusen_US
dc.subjectglycated haemoglobinen_US
dc.subjecttumor necrosis factor ?en_US
dc.subjectoxidized low density lipoproteinen_US
dc.titleCorrelation of glycated haemoglobin( HbA1c) with TNF-? and Oxidised-LDL in Type 2 DMen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
njppp2024v14n12p2607.pdf
Size:
803.01 KB
Format:
Adobe Portable Document Format
Download
Collections
National Journal of Physiology, Pharmacy and Pharmacology