Correlation of glycated haemoglobin( HbA1c) with TNF-? and Oxidised-LDL in Type 2 DM
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Date
2024-12
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?Eldaghayes Publisher
Abstract
Background: Type 2 diabetes mellitus (DM) is rising as a major health concern worldwide. The pathogenesis of DM and its complications involve an array of dynamic interactions between genes, inflammatory cytokines like TNF-?, oxidative stress, environmental factors, and lifestyle. Several studies have shown a strong correlation of Ox-LDL (Ox- idized low-density lipoprotein) and TNF-? (tumor necrosis factor-?) with IR (insulin resistance). Hence, the present study was designed to study the correlation between HbA1c (glycated hemoglobin) (a marker of glycemic control) with TNF-? (a marker of chronic inflammation) and Ox-LDL (a marker of oxidative stress). Aim and objectives: To study the correlation between TNF-? and Ox-LDL with HbA1c in Type 2 DM. Methods: For our pilot study, we recruited patients with type 2 DM belonging to the age group 35-50 years of either gender from Medicine OPD as cases. The institutional ethics committee approval has been taken before commence- ment of the study. After informed consent from patients, venous blood samples were collected and analyzed using a biochemistry autoanalyzer and appropriate ELISA kit. Data were analyzed statistically using SPSS software. Result: The study showed raised levels of HbA1c, TNF-?, and OX-LDL in type 2 DM patients. Conclusion: Furthermore, a significant positive correlation was observed between TNF-? and HbA1c (r = 0.829) and also between Ox-LDL and HbA1c (r = 0.638).
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Keywords
type 2 diabetes mellitus, glycated haemoglobin, tumor necrosis factor ?, oxidized low density lipoprotein
Citation
Pawar P, Dhama A, Chahal A, Ghalaut VS.. Correlation of glycated haemoglobin( HbA1c) with TNF-? and Oxidised-LDL in Type 2 DM . National Journal of Physiology, Pharmacy and Pharmacology. 2024 Dec; 14(12): 2607-2611