In vitro study on the antioxidant activity of methanolic leaf extract of Carica papaya

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dc.contributor.authorAboobacker, Haseena K.en_US
dc.contributor.authorValoth, Gopeshen_US
dc.contributor.authorKizhedath, Sabeenaen_US
dc.date.accessioned2020-04-23T08:01:42Z
dc.date.available2020-04-23T08:01:42Z
dc.date.issued2020-04
dc.description.abstractBackground: Newer drug research worldwide is now focusing on medicinal plants for ensuring health and vitality due to the seemingly safer side effect profile and abundance of plants in nature, compared to synthetic drugs. Antioxidants are vital in preventing free radical induced tissue damage. The purpose of the present study is to evaluate the antioxidant activity of the methanolic extract of the leaves of Carica papaya using 1,1-diphenyl-2-picrylhydrazine (DPPH). Phytochemical tests proved the presence of bioactive ingredients in the extract.Methods: DPPH free radical assay, one of the most accurate methods for evaluating antioxidant activity, was used to evaluate the antioxidant activity of methanolic extract of leaves of C. papaya.Results: The methanolic leaf extract of C. papaya showed antioxidant property with free radical scavenging activity increasing with increase in concentration. The IC50 value of methanolic extract was 213.68 礸m/ml. Ascorbic acid was used as control.Conclusions: Oxidative stress has been linked to heart disease, cancer, immune deficiency. Antioxidants as suggested from various studies may reduce the risk of such diseases. The utility of C. papaya in the treatment of heart disease, cancer and immune deficiency will have to be proved by detailed evaluation of its pharmacological properties.en_US
dc.identifier.affiliationsDepartment of Pharmacology, Govt. Medical College Thrissur, Kerala, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmacology, Govt. Medical College, Manjeri, Kerala, Indiaen_US
dc.identifier.citationAboobacker Haseena K., Valoth Gopesh, Kizhedath Sabeena. In vitro study on the antioxidant activity of methanolic leaf extract of Carica papaya. International Journal of Basic & Clinical Pharmacology. 2020 Apr; 9(4): 652-656en_US
dc.identifier.issn2319-2003
dc.identifier.issn2279-0780
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/200588
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber4en_US
dc.relation.volume9en_US
dc.source.urihttps://dx.doi.org/10.18203/2319-2003.ijbcp20201194en_US
dc.subjectCarica papayaen_US
dc.subjectAntioxidant activityen_US
dc.subjectDPPHen_US
dc.subjectIC50en_US
dc.titleIn vitro study on the antioxidant activity of methanolic leaf extract of Carica papayaen_US
dc.typeJournal Articleen_US
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