A study on the safety and tolerability of mycophenolate mofetil in patients with connective tissue disease

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dc.contributor.authorDas, Subhamen_US
dc.contributor.authorPadhan, Prasantaen_US
dc.date.accessioned2020-04-23T07:52:32Z
dc.date.available2020-04-23T07:52:32Z
dc.date.issued2018-11
dc.description.abstractBackground: Connective tissue disorders (CTD) are mostly due to inflammatory and fibrotic tissue injury. Glucocorticoids and immunomodulators though useful but are toxic. Mycophenolate mofetil (MMF) is now being used successfully in many autoimmune diseases, but the safety of MMF in CTD patients is yet to be conclusively established.Methods: The study was a retrospective record based observational one in patients of CTD satisfying the predetermined inclusion criteria. Various safety parameters were noted down from the observed records and analysed accordingly.Results: The 120 case records of CTD patients were analysed for a specific set of safety parameters over the preceding one year. Diarrhoeal attacks were the most commonly encountered side effect (38.3%) of long term patients who were on mycophenolate therapy followed by infection.Conclusions: Mycophenolate was found to be generally well tolerated in CTD patients with few reports of adverse events, but larger clinical trials are needed to conclusively establish its safety.en_US
dc.identifier.affiliationsDepartment of Pharmacology, GIMSH, Durgapur, West Bengal, Indiaen_US
dc.identifier.affiliationsDepartment of Rheumatology, KIMS, Bhuvneshwar, Odisha, Indiaen_US
dc.identifier.citationDas Subham, Padhan Prasanta. A study on the safety and tolerability of mycophenolate mofetil in patients with connective tissue disease. International Journal of Basic & Clinical Pharmacology. 2018 Nov; 7(11): 2169-2172en_US
dc.identifier.issn2319-2003
dc.identifier.issn2279-0780
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/199901
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber11en_US
dc.relation.volume7en_US
dc.source.urihttps://dx.doi.org/10.18203/2319-2003.ijbcp20184322en_US
dc.subjectAutoimmune diseaseen_US
dc.subjectConnective tissue disordersen_US
dc.subjectCTDen_US
dc.subjectImmunomodulatorsen_US
dc.subjectMycophenolate mofetilen_US
dc.titleA study on the safety and tolerability of mycophenolate mofetil in patients with connective tissue diseaseen_US
dc.typeJournal Articleen_US
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