Effect of nonsurgical periodontal therapy on interleukin-34 levels in periodontal health and disease

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dc.contributor.authorGuruprasad, CNen_US
dc.contributor.authorPradeep, ARen_US
dc.date.accessioned2020-01-02T06:45:13Z
dc.date.available2020-01-02T06:45:13Z
dc.date.issued2018-05
dc.description.abstractInterleukin-34 (IL-34) is a recently identified alternative ligand for colony-stimulating factor-1 receptor plays an important role in osteoclastogenesis. The aim of this study was to evaluate the IL-34 levels in gingival crevicular fluid (GCF) and plasma in subjects with chronic periodontitis and to evaluate the effect of nonsurgical periodontal therapy on the GCF and plasma IL-34 levels. Materials and Methods: Thirty individuals (age range: 30–56 years) were selected and divided into groups based on the gingival index, probing pocket depth, clinical attachment level, and radiologic parameters (bone loss): Group I (15 individuals with healthy periodontium), Group II (15 individuals with chronic generalized periodontitis) while Group II patients after 8 weeks of the treatment (scaling and root planning) constituted Group III. GCF samples and plasma samples were collected to estimate the levels of IL-34 using enzyme-linked immunosorbent assay kit. Results: The mean IL-34 concentration in GCF and plasma was highest for Group II compared to Group I and decreased after nonsurgical periodontal therapy in chronic generalized periodontitis group. The difference between them was statistically significant (P < 0.05). Conclusion: IL-34 can be considered as an “inflammatory marker” of periodontal disease and can be explored in the future as a potential therapeutic target in the treatment of periodontal disease.en_US
dc.identifier.affiliationsDepartment of Periodontology, Government Dental College and Research Institute, Bengaluru, Karnataka, Indiaen_US
dc.identifier.citationGuruprasad CN, Pradeep AR. Effect of nonsurgical periodontal therapy on interleukin-34 levels in periodontal health and disease. Indian Journal of Dental Research. 2018 May; 29(3): 280-285en_US
dc.identifier.issn0970-9290
dc.identifier.issn1998-3603
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/192089
dc.languageenen_US
dc.publisherIndian Society for Dental Researchen_US
dc.relation.issuenumber3en_US
dc.relation.volume29en_US
dc.source.urihttps://dx.doi.org/10.4103/ijdr.IJDR_527_17en_US
dc.subjectGingival crevicular fluiden_US
dc.subjectperiodontitisen_US
dc.subjectplasmaen_US
dc.titleEffect of nonsurgical periodontal therapy on interleukin-34 levels in periodontal health and diseaseen_US
dc.typeJournal Articleen_US
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