The metabolic syndrome is associated with increased risk of colorectal adenoma development: the Self-Defense Forces health study.

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dc.contributor.authorMorita, Takakoen_US
dc.contributor.authorTabata, Shinjien_US
dc.contributor.authorMineshita, Masamichien_US
dc.contributor.authorMizoue, Tetsuyaen_US
dc.contributor.authorMoore, Malcolm Aen_US
dc.contributor.authorKono, Suminorien_US
dc.date.accessioned2009-05-27T17:32:06Z
dc.date.available2009-05-27T17:32:06Z
dc.date.issued2005-10-27en_US
dc.descriptionAsian Pacific Journal of Cancer Prevention.en_US
dc.description.abstractThe metabolic syndrome, a cluster of metabolic abnormalities linked to insulin resistance, has attracted much interest as a risk factor for cardiovascular disease and type 2 diabetes. Hyperinsulinemia is also a postulated biological risk factor for colorectal carcinogenesis. We therefore here examined the relation between the metabolic syndrome and colorectal adenoma development. The study subjects were 756 cases of colorectal adenoma and 1751 controls with no polyps who underwent total colonoscopy during the period January 1995 to March 2002 at two Self Defense Forces (SDF) hospitals in Japan. The metabolic syndrome was defined with reference to abdominal obesity in combination with any two of the following conditions: elevated triglycerides (150 mg/dL); lowered HDL cholesterol (<40 mg/dL); elevated blood pressure (systolic blood pressure 130 mmHg and/or diastolic blood pressure 85 mmHg); and raised fasting glucose (110 mg/dL). Abdominal obesity was defined as a waist circumference of 85 cm or more(Japanese criterion) or 90 cm (Asian criterion). Statistical adjustment was made for age, hospital, and rank in the SDF. The metabolic syndrome was found to be associated with a moderately increased risk of colorectal adenomas whether either of the Japanese and Asian criteria was used; adjusted odds ratios with the Japanese and Asian criteria were 1.38 (95% confidence interval [CI] 1.13-1.69) and 1.48 (95% CI 1.13-1.93), respectively. Increased risk was more evident for proximal than distal colon or rectal adenomas, and was almost exclusively observed for large lesions (5 mm in diameter). Thus the metabolic syndrome appears to be an important entity with regard to the prevention of colorectal cancer, as well as cardiovascular disease and type 2 diabetes.en_US
dc.description.affiliationDepartment of Preventive Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.en_US
dc.identifier.citationMorita T, Tabata S, Mineshita M, Mizoue T, Moore MA, Kono S. The metabolic syndrome is associated with increased risk of colorectal adenoma development: the Self-Defense Forces health study. Asian Pacific Journal of Cancer Prevention. 2005 Oct-Dec; 6(4): 485-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/37351
dc.language.isoengen_US
dc.source.urihttps://www.apocp.orgen_US
dc.subject.meshAdenoma --ethnologyen_US
dc.subject.meshAdulten_US
dc.subject.meshAsian Continental Ancestry Groupen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshColonic Neoplasms --ethnologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMetabolic Syndrome X --complicationsen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMilitary Personnelen_US
dc.subject.meshOdds Ratioen_US
dc.subject.meshRectal Neoplasms --ethnologyen_US
dc.titleThe metabolic syndrome is associated with increased risk of colorectal adenoma development: the Self-Defense Forces health study.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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