Outcome of poisonous snake bites treated with high dose anti snake venom serum versus low dose –A critical review

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dc.contributor.authorNatarajan, Sen_US
dc.contributor.authorRajagopal, A.en_US
dc.date.accessioned2019-12-02T10:11:48Z
dc.date.available2019-12-02T10:11:48Z
dc.date.issued2019
dc.description.abstractBackground: In India, about 1 million people are bitten by snakes more in the rural area and they get admitted to hospitals. About 50,000, people die of snake bites every year in India. The patients admitted with poisonous snake bites were treated with polyvalent anti snake venom serum. Aim: To determine the significant difference and outcome between High Dose and Low dose Polyvalent Anti Snake Venom Serum (PVASVS), with regards to age gender and severity of coagulation abnormalities. The cost of ASV has an economic impact and if low dose ASV saves the scarce resource. Materials and Methods: 45 patients bitten by snake admitted and treated which included both males and females were taken up for this study based on Poisson model of sampling. All the patients had cellulitis, renal failure and varying degree of coagulation abnormalities. They were classified into LDG and HDG depending on the number of PVASVS they received which was ≤25 vials or >25 vials respectively. This was decided based on the treatment of ASV analyzed using chi-square contingency statistically for its significance. Results: The age and clotting time as such do not have association to distinguish HDG or LDG. It was revealed that Gender has an effect that female HDG are 26.3% (5 out of 19) as compared to male 73.7% (14 out of 19). In each group, 2 patients died out of 18, LDG (11%) 27 in HDG (7.4%) 62.9% of patients in LDG and 38.8% in HDG required hospital stay more than 10 days. Conclusions: The female gender falls in low dose conserving ASV. The LD ASV demands higher duration of stay (more than 10 days) in the hospital. The age, coagulation abnormality did not establish the significant results in the LDG and HDG.en_US
dc.identifier.affiliationsAssociate Professor, KMCH Medical College, Coimbatore, Tamil Nadu, India, drnatarajan.s@gmail.comen_US
dc.identifier.affiliationsHead, Indian Statistical Institute, Coimbatore, Tamil Nadu, Indiaen_US
dc.identifier.citationNatarajan S, Rajagopal A.. Outcome of poisonous snake bites treated with high dose anti snake venom serum versus low dose –A critical review. International Archives of Integrated Medicine. 2019 Oct; 6(10):en_US
dc.identifier.issn2394-0026
dc.identifier.issn2394-0034
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/187366
dc.languageenen_US
dc.publisherEducational Society for Excellenceen_US
dc.relation.issuenumber10en_US
dc.relation.volume6en_US
dc.subjectSnake Bitesen_US
dc.subjectPoly valent anti snake venom serum (PVASVS)en_US
dc.subjectHigh dose group (HDG)en_US
dc.subjectLow dose group (LDG)en_US
dc.subjectDialysisen_US
dc.subjectRenal Failureen_US
dc.subjectCellulitisen_US
dc.subjectDisseminated Intra Vascular Coagulation (DIVC)en_US
dc.subjectClotting time (CT)en_US
dc.titleOutcome of poisonous snake bites treated with high dose anti snake venom serum versus low dose –A critical reviewen_US
dc.typeJournal Articleen_US
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