Prevalence of ESBL producing enterobacteriaceae in diabetic foot ulcers

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dc.contributor.authorAnitha, Sen_US
dc.contributor.authorNatarajan, Ven_US
dc.date.accessioned2019-12-02T10:00:03Z
dc.date.available2019-12-02T10:00:03Z
dc.date.issued2017
dc.description.abstractIntroduction: Diabetic foot ulcer is one of the dreaded complications among the diabetic patients which are disabling, leading to repeated hospitalizations and even amputation, drastically reducing the quality of life. Hence proper management of diabetic foot infections by choosing appropriate antibiotic is crucial. The aim of the study: This study was undertaken to know about the prevalence of ESBL producing Enterobacteriaceae in Diabetic foot ulcers and their antibiotic sensitivity pattern to aid in the effective treatment of infection. Materials and methods: A total of 200 Pus samples were collected from the patients admitted and/ or attending in-patient or out-patient departments of Rajah Muthiah Medical College and Hospital. Only Enterobacteriaceae were isolated and antibiotic sensitivity testing was done according to CLSI guidelines. All the isolates were screened for ESBL and confirmed by phenotypic confirmatory tests. Results: A total of 60 Enterobacteriaceae were isolated from diabetic foot ulcer patients among which 27 (45%) isolates were ESBL producers. ESBL production is predominantly seen in E.coli (48.1%) followed by Klebsiella (44.4%), P. mirabilis (3.3%) and P. vulgaris (3.3%). ESBL producers were sensitive to Imipenam (88.9%), Amikacin (77.8%) and Gentamicin (55.6%) whereas highly resistant to Ampicillin, Amoxyclav, Cefuroxime and Ceftriaxone. Conclusion: This study shows the higher prevalence of ESBL producing Enterobacteriaceae in diabetic foot ulcers. Imipenam, Amikacin and Gentamicin can be used for empirical treatment but early identification and treatment according to antibiotic sensitivity pattern helps in preventing the emergence and propagation of multidrug resistance strains.en_US
dc.identifier.affiliationsPost Graduate, Department of Microbiology, Rajah Muthiah Medical College, Annamalai University, Chidambaram, Tamil Nadu, India, anithagalu@gmail.comen_US
dc.identifier.affiliationsProfessor and HOD, Department of Microbiology, Rajah Muthiah Medical College, Annamalai University, Chidambaram, Tamil Nadu, Indiaen_US
dc.identifier.citationAnitha S, Natarajan V. Prevalence of ESBL producing enterobacteriaceae in diabetic foot ulcers. International Archives of Integrated Medicine. 2017 Nov; 4(11): 122-127en_US
dc.identifier.issn2394-0026
dc.identifier.issn2394-0034
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/186704
dc.languageenen_US
dc.publisherEducational Society for Excellenceen_US
dc.relation.issuenumber11en_US
dc.relation.volume4en_US
dc.subjectESBLen_US
dc.subjectDiabetic foot ulcersen_US
dc.subjectEnterobacteriaceaeen_US
dc.subjectGram-negative bacteriaen_US
dc.titlePrevalence of ESBL producing enterobacteriaceae in diabetic foot ulcersen_US
dc.typeJournal Articleen_US
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