Interim Analysis of Outcome in Postoperative Cases of Squamous Cell Cancer of Oral Cavity Receiving Adjuvant Radiotherapy/Radiochemotherapy: An Observational Descriptive Study

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dc.contributor.authorSingh, Rashmien_US
dc.contributor.authorKumari, Vinitaen_US
dc.contributor.authorKushwaha, Ajit Kumaren_US
dc.date.accessioned2025-06-18T10:11:58Z
dc.date.available2025-06-18T10:11:58Z
dc.date.issued2025-04
dc.description.abstractIntroduction: Squamous cell carcinoma of the oral cavity and lip is the most common type of head?and?neck cancer in India. Various tumor and treatment?related factors influence locoregional control. We aim to assess the impact of these prognostic factors on 2?year disease?free survival (DFS) in postoperative cases of cancer in the oral cavity. We present the interim analysis of our study. Materials and Methods: This was a prospective observational descriptive study conducted in the radiation oncology department. An interim analysis was performed at a minimum of 6 months following radiotherapy or sooner if an event occurred. Patients received either postoperative radiotherapy or chemoradiotherapy, depending on the presence of risk factors. We documented histopathological parameters and treatment?related factors. To evaluate the impact of risk factors on survival, we applied the log?rank test and Cox regression analysis. P ? 0.05 was considered statistically significant. Results: A total of 22 patients were included in this interim analysis. The median DFS was 5.6 months. Kaplan–Meier survival analysis revealed that DFS was significantly poorer in patients with a higher pathological nodal (pN) stage (P = 0.000), those with positive lymphovascular invasion (LVI+) compared to those with negative LVI (142.62 ± 47.07 days vs. 253.61 ± 10.5 days; P = 0.004), and those with positive extranodal extension (ENE+) compared to patients without ENE (90 ± 40.41 days vs. 254.32 ± 9.54 days; P = 0.000). In univariate analysis using Cox regression, higher pN status (hazard ratio [HR]: 4.802; confidence interval [CI]: 1.236–13.482; P = 0.021) and LVI+ (HR: 15; CI: 1.39–177.72; P = 0.029) were found to be associated with poor survival outcomes. Conclusions: In this interim analysis, DFS was significantly impacted by high nodal burden, ENE+, and the presence of LVI. Other pathological prognostic factors and treatment?related factors did not significantly affect DFS.en_US
dc.identifier.affiliationsDepartment of Radiation Oncology, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, Indiaen_US
dc.identifier.affiliationsDepartment of Radiation Oncology, Park Hospital, Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Surgical Oncology, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, Indiaen_US
dc.identifier.citationSingh Rashmi, Kumari Vinita, Kushwaha Ajit Kumar. Interim Analysis of Outcome in Postoperative Cases of Squamous Cell Cancer of Oral Cavity Receiving Adjuvant Radiotherapy/Radiochemotherapy: An Observational Descriptive Study. Acta Medica International. 2025 Apr; 12(1): 59-65en_US
dc.identifier.issn2349-0578
dc.identifier.issn2349-0896
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/247992
dc.languageenen_US
dc.publisherWolters Kluwer – Medknowen_US
dc.relation.issuenumber1en_US
dc.relation.volume12en_US
dc.source.urihttps://doi.org/10.4103/amit.amit_7_25en_US
dc.subjectCancer oral cavityen_US
dc.subjectdisease?free survivalen_US
dc.subjectnodal statusen_US
dc.subjectoutcomeen_US
dc.subjectprognostic factorsen_US
dc.titleInterim Analysis of Outcome in Postoperative Cases of Squamous Cell Cancer of Oral Cavity Receiving Adjuvant Radiotherapy/Radiochemotherapy: An Observational Descriptive Studyen_US
dc.typeJournal Articleen_US
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