A New Validated Third Order Derivative Spectroscopic Method For Simultaneous Estimation Of Metoprolol Succinate And Ramipril In Tablet Dosage Form

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dc.contributor.authorB., A.en_US
dc.contributor.authorSindhusha, M.en_US
dc.contributor.authorRaul, S. K.en_US
dc.contributor.authorPadhy, G. K.en_US
dc.date.accessioned2020-09-24T08:01:48Z
dc.date.available2020-09-24T08:01:48Z
dc.date.issued2020-05
dc.description.abstractObjective: The objective of the present work is to develop and validate a new UV derivative spectrophotometric method for simultaneous estimation of metoprolol succinate and ramipril in methanol: water (50:50v/v). Methods: “Zero crossing technique” was chosen for quantitative determination. The zero-crossing points (ZCP’s) were found to be 209 nm where metoprolol succinate was quantified and 211 nm where ramipril was quantified. This method was then subjected to accuracy, linearity, sensitivity and reproducibility according to ICH guidelines to ensure and confirm its validity. Results: The method was found to be obeying Beer’s law in the range of 10-50 µg/ml and 5-25 µg/ml for metoprolol succinate and ramipril, respectively. The % recoveries were observed between the range of 99.2-100.2 for metoprolol succinate and 99.57-99.86 for ramipril. The intra-day and inter-day results showed reproducibility. Conclusion: It can be concluded that the developed third-order UV derivative spectroscopic method for the simultaneous determination of metoprolol succinate and ramiprilcan be recommended for routine quantitative analysis.en_US
dc.identifier.affiliationsDepartment of Pharmaceutical Analysis and Quality Assurance, Maharajah’s College of Pharmacy, Phool Baugh, Vizianagaram 535002, Andhra Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmaceutical Analysis and Quality Assurance, Maharajah’s College of Pharmacy, Phool Baugh, Vizianagaram 535002, Andhra Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmaceutical Analysis and Quality Assurance, Maharajah’s College of Pharmacy, Phool Baugh, Vizianagaram 535002, Andhra Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmaceutical Analysis and Quality Assurance, Maharajah’s College of Pharmacy, Phool Baugh, Vizianagaram 535002, Andhra Pradesh, Indiaen_US
dc.identifier.citationB. A., Sindhusha M., Raul S. K., Padhy G. K.. A New Validated Third Order Derivative Spectroscopic Method For Simultaneous Estimation Of Metoprolol Succinate And Ramipril In Tablet Dosage Form. International Journal of Pharmacy and Pharmaceutical Sciences. 2020 May; 12(5): 47-53en_US
dc.identifier.issn0975-1491
dc.identifier.issn2656-0097
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/206093
dc.languageenen_US
dc.publisherInnovare Academic Sciences Pvt. Ltd.en_US
dc.relation.issuenumber5en_US
dc.relation.volume12en_US
dc.source.urihttps://doi.org/10.22159/ijpps.2020v12i5.36413en_US
dc.subjectThird orderen_US
dc.subjectUV derivative spectroscopyen_US
dc.subjectMetoprolol succinateen_US
dc.subjectRamiprilen_US
dc.subjectValidationen_US
dc.subjectZero crossing techniqueen_US
dc.titleA New Validated Third Order Derivative Spectroscopic Method For Simultaneous Estimation Of Metoprolol Succinate And Ramipril In Tablet Dosage Formen_US
dc.typeJournal Articleen_US
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