Some Chemical Carcinogens for Leukaemia Induction and Their Animal Models

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dc.contributor.authorAliyu, Abdullahien_US
dc.contributor.authorShaari, Mohd Roslyen_US
dc.contributor.authorMustapha, Noordin Mohameden_US
dc.contributor.authorSayuti, Nurul Syahirah Ahmaden_US
dc.contributor.authorReduan, Mohd Farhan Hanifen_US
dc.contributor.authorSithambaram, Shanmugaveluen_US
dc.contributor.authorShaari, Khozirahen_US
dc.contributor.authorHamzah, Hazilawatien_US
dc.date.accessioned2019-12-06T09:19:17Z
dc.date.available2019-12-06T09:19:17Z
dc.date.issued2019-09
dc.description.abstractAnimal models have been providing invaluable contributions to the better understanding of mechanisms of cancer (including leukaemias) development and effectiveness of most of the treatments. Chemical carcinogens are generally used to study the biology of cancers including leukaemias in many animal models, including rats and mice. The studies in most cases are aimed at the development and evaluation of cancer treatments and preventions. Some of the most common chemical carcinogens used in animal models for leukaemias include N-ethyl-N-nitrosourea (ENU), N-methyl-N-nitrosourea (MNU), dimethyl benz(a)anthracene (DMBA) and benzo(a)pyrene (BaP). This review provides highlights on different animal models of leukaemia induced by the chemical carcinogens mentioned earlier, at the same time discussing the contributions of these models to the leukaemia diagnosis in laboratory animal models for subsequent development of treatment.en_US
dc.identifier.affiliationsDepartment of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia and Department of Veterinary Pathology, Usmanu Danfodiyo University, Sokoto, Nigeria.en_US
dc.identifier.affiliationsAnimal Science Research Centre, Malaysian Agricultural Research and Development Institute, Headquarter, 43400, Serdang, Selangor, Malaysia.en_US
dc.identifier.affiliationsDepartment of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia.en_US
dc.identifier.affiliationsDepartment of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia.en_US
dc.identifier.affiliationsDepartment of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia.en_US
dc.identifier.affiliationsAnimal Science Research Centre, Malaysian Agricultural Research and Development Institute, Headquarter, 43400, Serdang, Selangor, Malaysia.en_US
dc.identifier.affiliationsDepartment of Chemistry, Faculty of Science, Universiti Putra Malaysia, Selangor 43400, Malaysia.en_US
dc.identifier.affiliationsDepartment of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia.en_US
dc.identifier.citationAliyu Abdullahi, Shaari Mohd Rosly, Mustapha Noordin Mohamed, Sayuti Nurul Syahirah Ahmad, Reduan Mohd Farhan Hanif, Sithambaram Shanmugavelu, Shaari Khozirah, Hamzah Hazilawati. Some Chemical Carcinogens for Leukaemia Induction and Their Animal Models. Annual Research & Review in Biology. 2019 Sep; 33(1): 1-7en_US
dc.identifier.issn2347-565X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/188091
dc.languageenen_US
dc.publisherScience Domain Internationalen_US
dc.relation.issuenumber1en_US
dc.relation.volume33en_US
dc.source.urihttps://doi.org/10.9734/arrb/2019/v33i130108en_US
dc.subjectAnimal modelen_US
dc.subjectDimethyl Benzanthracene (DMBA)en_US
dc.subjectBenzo (a) pyrene (BaP)en_US
dc.subjectLeukaemiaen_US
dc.subjectN-ethyl-N-nitrosourea (ENU)en_US
dc.subjectN-methyl-N-nitrosourea (MNU)en_US
dc.titleSome Chemical Carcinogens for Leukaemia Induction and Their Animal Modelsen_US
dc.typeJournal Articleen_US
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