Effect of acute exposure of triazophos on oxidative stress and histopathological alterations in liver, kidney and brain of Wistar rats.

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dc.contributor.authorMohineesh
dc.contributor.authorRaj, Jaya
dc.contributor.authorRajvanshi, A C
dc.contributor.authorDogra, T D
dc.contributor.authorRaina, Anupuma
dc.date.accessioned2014-12-11T11:07:11Z
dc.date.available2014-12-11T11:07:11Z
dc.date.issued2014-08
dc.description.abstractAcute dose of organophosphorus pesticide Triazophos (O,O-diethyl O-1-phenyl-1H-1,2,4-triazol-3-yl phosphorothioate; Tz) administered orally affects oxidative stress parameters and the histo-architecture of liver, kidney and brain tissues. The results indicate a dose dependent induction of oxidative stress as evident by increased malondialdehyde level and decreased antioxidant defense including glutathione and superoxide dismutase activity in rat liver, kidney and brain. AChE activity was found significantly decreased in the Tz treated groups as compared to the vehicle control (DMSO) group. Histopathological examination of liver, kidney and brain in Tz treated rats revealed medullary congestion and hydropic degeneration of hepatocytes in liver and medullary congestion in kidney. However, no significant histopathological changes were observed in brain tissues.en_US
dc.identifier.citationMohineesh, Raj Jaya, Rajvanshi A C, Dogra T D, Raina Anupuma. Effect of acute exposure of triazophos on oxidative stress and histopathological alterations in liver, kidney and brain of Wistar rats. Indian Journal of Experimental Biology. 2014 Aug; 52(8): 814-819.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/153764
dc.language.isoenen_US
dc.source.urihttps://nopr.niscair.res.in/handle/123456789/29300en_US
dc.subjectAcetyl cholinesteraseen_US
dc.subjectGlutathioneen_US
dc.subjectLipid peroxidationen_US
dc.subjectSuperoxide dismutaseen_US
dc.subjectTriazophosen_US
dc.subject.meshAnimals
dc.subject.meshAntioxidants --metabolism
dc.subject.meshBrain --drug effects
dc.subject.meshGlutathione --metabolism
dc.subject.meshKidney --drug effects
dc.subject.meshLipid Peroxidation --drug effects
dc.subject.meshLiver --drug effects
dc.subject.meshMalondialdehyde --metabolism
dc.subject.meshOrganothiophosphates --toxicity
dc.subject.meshOxidative Stress --drug effects
dc.subject.meshPesticides --toxicity
dc.subject.meshRats
dc.subject.meshTriazoles --toxicity
dc.titleEffect of acute exposure of triazophos on oxidative stress and histopathological alterations in liver, kidney and brain of Wistar rats.en_US
dc.typeArticleen_US
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