Assessment of drug-drug interactions in the prescription of elderly patients on cardiovascular drugs

Simple item page
dc.contributor.authorC., Snehaen_US
dc.contributor.authorH. V., Anuradhaen_US
dc.contributor.authorKulkarni, Srihari G.en_US
dc.date.accessioned2020-04-23T07:55:46Z
dc.date.available2020-04-23T07:55:46Z
dc.date.issued2019-05
dc.description.abstractBackground: Cardiovascular disease is one of the major causes of mortality and morbidity in a developing country like India. These patient’s prescription contains multiple drugs to reduce the mortality and morbidity and they also contain drugs for treatment of co morbidities leading to polypharmacy. The main objective of the study was to identify the pattern of drug- drug interaction (DDI) in patients on cardiovascular drugs with various co existing morbidities.Methods: This study was conducted in the Department of General Medicine of a tertiary care center. Prescription of 200 patients were analysed for demographic details like gender, age, comorbidities and drugs prescribed. DDI were assessed using Micromedex software.Results: In this study, conducted on the prescription of 200 elderly patients, 13 (66%) prescription had 408 DDI, of which 158 (39%) were major, 246 (60%) were moderate and 1 (0.02%) was contraindicated and 3 (0.007%) were minor.Conclusions: It can be concluded from the present study that the risk of DDI increases with the increase in number of drugs in the prescription and there is increase in number of drugs in the prescription with the increase in number of co morbidities. The antiplatelet and anticoagulant group of drugs were responsible for majority of DDI, followed by antihypertensives and hypoglycaemic agents. Most of these DDI could be avoided with slight modification in the dosage regimen based on the pharmacokinetics and pharmacodynamics of the drug.en_US
dc.identifier.affiliationsDepartment of Pharmacology, MS Ramaiah Medical College and Hospital, Bangalore, Karnataka, Indiaen_US
dc.identifier.citationC. Sneha, H. V. Anuradha, Kulkarni Srihari G.. Assessment of drug-drug interactions in the prescription of elderly patients on cardiovascular drugs. International Journal of Basic & Clinical Pharmacology. 2019 May; 8(5): 1078-1082en_US
dc.identifier.issn2319-2003
dc.identifier.issn2279-0780
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/200161
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber5en_US
dc.relation.volume8en_US
dc.source.urihttps://dx.doi.org/10.18203/2319-2003.ijbcp20191604en_US
dc.subjectCardiovascular drugsen_US
dc.subjectDrug-drug interactionen_US
dc.subjectMajor interactionen_US
dc.subjectModerate interactionen_US
dc.titleAssessment of drug-drug interactions in the prescription of elderly patients on cardiovascular drugsen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ijbcp2019v8n5p1078.pdf
Size:
213.34 KB
Format:
Adobe Portable Document Format
Download
Collections
International Journal of Basic & Clinical Pharmacology