Tri-iodo thyronine regulates antioxidant enzyme activities in different cell fractions through a mechanism sensitive to actinomycin D in a teleost, Anabas testudineus (Bloch).

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dc.contributor.authorSaumya, S Men_US
dc.contributor.authorSreejith, Pen_US
dc.contributor.authorVijayasree, A Sen_US
dc.contributor.authorDivya, Len_US
dc.contributor.authorManju, Men_US
dc.contributor.authorOommen, O Ven_US
dc.date.accessioned2009-05-28T11:34:19Z
dc.date.available2009-05-28T11:34:19Z
dc.date.issued2006-08-24en_US
dc.description.abstractThe present study evaluated the effects of hyperthyroid state on lipid peroxidation and antioxidant enzymes in the crude (CF), post nuclear (PNF) and mitochondrial fractions (MF) of the fish liver. The in vivo injection of T3 (200ng) did not change the lipid peroxidation products, malondialdehyde (MDA) and conjugated dienes (CD), while actinomycin D (10microg), a potent mRNA inhibitor when administered with T3 increased them. The antioxidant enzymes like superoxide dismutase (SOD) and catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR) had an increased activity in CF and MF of hyperthyroid group to compete the increased oxidative stress, but actinomycin D partially inhibited the T3-induced activity. SOD and CAT activities in PNF of hyperthyroid group had no change, the glutathione concentration varied depending on the GPx and GR activity. Hyperthyroidism decreased the protein content, while simultaneous administration of actinomycin D inhibited the T3 action of elevating the protein content. The results suggest that the antioxidant defense status in A. testudineus is modulated by thyroid hormone, through an action sensitive to actinomycin D.en_US
dc.description.affiliationDepartment of Zoology, University of Kerala, Kariavattom, India.en_US
dc.identifier.citationSaumya SM, Sreejith P, Vijayasree AS, Divya L, Manju M, Oommen OV. Tri-iodo thyronine regulates antioxidant enzyme activities in different cell fractions through a mechanism sensitive to actinomycin D in a teleost, Anabas testudineus (Bloch). Indian Journal of Experimental Biology. 2006 Aug; 44(8): 640-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/56900
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.source.urihttps://nopr.niscair.res.in/bitstream/123456789/6559/1/IJEB%2044%288%29%20640-646.pdfen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntioxidants --metabolismen_US
dc.subject.meshDactinomycin --pharmacologyen_US
dc.subject.meshGlutathione --metabolismen_US
dc.subject.meshLipid Peroxidation --drug effectsen_US
dc.subject.meshPerciformes --metabolismen_US
dc.subject.meshTriiodothyronine --pharmacologyen_US
dc.titleTri-iodo thyronine regulates antioxidant enzyme activities in different cell fractions through a mechanism sensitive to actinomycin D in a teleost, Anabas testudineus (Bloch).en_US
dc.typeJournal Articleen_US
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