The Susceptibility to Rubella Virus Infection among Pregnant Women Attending Antenatal Clinics in Unguja, Zanzibar: The Need to Employ Multiple Strategies to Control Congenital Rubella Syndrome in Tanzania

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dc.contributor.authorMirambo, MMen_US
dc.contributor.authorNyawale, Hen_US
dc.contributor.authorMichael, Fen_US
dc.contributor.authorMamba, Pen_US
dc.contributor.authorHassan, Ken_US
dc.contributor.authorAli, HMen_US
dc.contributor.authorMinja, CAen_US
dc.contributor.authorDamiano, Pen_US
dc.contributor.authorMshana, SE.en_US
dc.date.accessioned2024-11-30T05:45:58Z
dc.date.available2024-11-30T05:45:58Z
dc.date.issued2023-12
dc.description.abstractAims: This study was conducted to determine the proportion of pregnant women susceptible to Rubella virus infection in Zanzibar, the information that might be useful in future control interventions. Study Design: A cross-sectional hospital-based study. Place and Duration of Study: The study was conducted in Unguja Zanzibar between May 2023 and July 2023. Methodology: Sociodemographic and other relevant information were collected from pregnant women attending antenatal clinics using structured questionnaires. Blood samples were collected from each consented woman. Detection of Rubella IgG antibodies was done by an indirect Enzyme Linked Immunosorbent Assay. Data analysis was done by using STATA version 15. Results: The median age of enrolled participants was 27[Interquartile range (IQR): 23-31] years while the median gestation age was 28 [IQR: 20-32] weeks. Out of 171 participants, 10/171(5.8%) [95% Cl:2-9.6%] were negative to Rubella virus IgG antibodies indicating susceptibility to active Rubella virus infection that can lead to Congenital Rubella Syndrome. On multivariate analysis, history of congenital malformations (OR: 27.4, 95% CI: 1.29-580.5, p=0.033) was significantly associated with susceptibility to Rubella virus infection. Conclusion: Despite high level of natural immunity, there is a considerable proportion of pregnant women in Zanzibar susceptible to Rubella virus infection necessitating the need for multiple strategies to reach a goal of Congenital Rubella Syndrome elimination.en_US
dc.identifier.affiliationsDepartment of Microbiology and Immunology, Catholic University of Health and Allied Sciences, P.O. Box 1464, Mwanza, Tanzaniaen_US
dc.identifier.affiliationsDepartment of Microbiology and Immunology, Catholic University of Health and Allied Sciences, P.O. Box 1464, Mwanza, Tanzaniaen_US
dc.identifier.affiliationsMinistry of Health, Immunization and Vaccine Development Program, Dodoma, Tanzaniaen_US
dc.identifier.affiliationsDepartment of Microbiology and Immunology, Catholic University of Health and Allied Sciences, P.O. Box 1464, Mwanza, Tanzaniaen_US
dc.identifier.affiliationsZanzibar Health Research Institute (ZAHRI), P.O. Box 2481, Zanzibar, Tanzaniaen_US
dc.identifier.affiliationsSchool of Health and medical Sciences, The State University of Zanzibar, P.O. Box 164, Zanzibar, Tanzaniaen_US
dc.identifier.affiliationsDepartment of Biochemistry and Molecular Biology, Catholic University of Health and Allied Sciences, P.O. Box 1464, Mwanza, Tanzaniaen_US
dc.identifier.affiliationsDepartment of Microbiology and Immunology, Catholic University of Health and Allied Sciences, P.O. Box 1464, Mwanza, Tanzaniaen_US
dc.identifier.affiliationsDepartment of Microbiology and Immunology, Catholic University of Health and Allied Sciences, P.O. Box 1464, Mwanza, Tanzania.en_US
dc.identifier.citationMirambo MM, Nyawale H, Michael F, Mamba P, Hassan K, Ali HM, Minja CA, Damiano P, Mshana SE.. The Susceptibility to Rubella Virus Infection among Pregnant Women Attending Antenatal Clinics in Unguja, Zanzibar: The Need to Employ Multiple Strategies to Control Congenital Rubella Syndrome in Tanzania. International Journal of TROPICAL DISEASE & Health. 2023 Dec; 44(24): 41-48en_US
dc.identifier.issn2278-1005
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/235383
dc.languageenen_US
dc.publisherMs. M. B. Mondalen_US
dc.relation.issuenumber24en_US
dc.relation.volume44en_US
dc.source.urihttps://doi.org/10.9734/ijtdh/2023/v44i241508en_US
dc.subjectRubellaen_US
dc.subjectsusceptible pregnant womenen_US
dc.subjectCRSen_US
dc.subjectZanzibaren_US
dc.titleThe Susceptibility to Rubella Virus Infection among Pregnant Women Attending Antenatal Clinics in Unguja, Zanzibar: The Need to Employ Multiple Strategies to Control Congenital Rubella Syndrome in Tanzaniaen_US
dc.typeJournal Articleen_US
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