Serum Copper and Plasma Protein Status in Normal Pregnancy.
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Date
2012-12
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Abstract
Background: Gradual alteration of serum copper and some plasma protein levels may occur with
advancement of pregnancy, which is associated with increased maternal and infant morbidity and
mortality. Objective: To observe serum copper and plasma protein levels in normal pregnant women of
different trimesters in order to find out their nutritional status. Methods: This cross sectional study
was carried out in the Department of Physiology, Sir Salimullah Medical College (SSMC), Dhaka,
between 1st January 2010 and December 2010. Ninety normal pregnant women of different trimesters
with age 20-30 years were included in the study group. They were selected from Out Patient Department
of Obstetrics and Gynaecology, SSMC. Age matched 30 non-pregnant women were taken as control.
Serum copper level was measured by Spectrophotometric method, serum total protein and albumin
levels were estimated by standard method. Statistical analysis was done by one way ANOVA, Bonferroni
and Pearson’s correlation coefficient test as applicable. Results: Serum Cu levels were significantly
higher in all trimesters of pregnant women compared to control. Again, this value was significantly
higher in 3rd trimester than that of in 1st and 2nd trimester and also in 2nd trimester than that of in 1st
trimester. In addition, mean serum total protein level was significantly lower in 3rd trimester than
control but no statistically significant difference was observed among different trimesters. Again,
mean serum albumin level was significantly lower in 2nd and 3rd trimester than 1st trimester and control.
In addition, serum Cu concentration showed significant positive correlation with different trimesters
of gestation. Conclusion: This study reveals that hypercupremia along with hypoproteinemia occur
in pregnant women from 1st to 3rd trimester of gestation. This gradual alteration of micro and
macronutrients become more profound with advancement of pregnancy.
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Keywords
Serum copper, Plasma protein, Trimester, Pregnancy
Citation
Noor Nushrat, Jahan Nasim, Sultana Nayma. Serum Copper and Plasma Protein Status in Normal Pregnancy. Journal of Bangladesh Society of Physiologists. 2012 Dec; 7(2): 66-71.