Coats disease in infants, toddlers, and preschoolers: Clinical presentation and treatment outcomes

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dc.contributor.authorHansraj, Saarangen_US
dc.contributor.authorJalali, Subhadraen_US
dc.contributor.authorRaval, Vishalen_US
dc.date.accessioned2025-06-19T05:52:08Z
dc.date.available2025-06-19T05:52:08Z
dc.date.issued2025-05
dc.description.abstractPurpose: To study the stage of presentation, clinical features, and treatment outcomes of patients diagnosed with Coats disease in infants, toddlers, and preschoolers (aged ?5 years). Methods: A retrospective hospital?based study of 98 patients with Coats disease was conducted. Results: The mean age at presentation was 30 months (range, 4–60 months). Majority were males (n = 72, 73%) with unilateral presentation (n = 98, 100%). The most common stages at presentation were total retinal detachment (stage 3B; 36%), advanced end?stage disease (stage 5; 22%), and total retinal detachment with secondary glaucoma (stage 4; 16%). The most common cause of referral to our institution was Coats disease (n = 23, 49%), followed by retinoblastoma (n = 17, 36%). The most common presenting symptom was a white reflex (n = 49, 50%) or strabismus observed by the parents (n = 34, 35%). Treatment modalities included observation (n = 30 eyes, 31%), surgical intervention (n = 22, 22%), and laser photocoagulation ± cryotherapy ± intravitreal injection (n = 22, 22%). At a mean follow?up of 29 months (range, 1–100 months), the anatomical status of the disease remained unchanged in 35 eyes (36%), worsened in 18 eyes (18%), and resolved in 15 eyes (15%). Ten eyes (10%) underwent enucleation. At the last follow?up, two?thirds of eyes (n = 76) had visual acuity ?20/400 and were categorized as blind. Conclusion: Coats disease in patients ?5 years presents at an advanced stage (3B or more). At the last follow?up, the disease had stabilized in half of the eyes, whereas two?thirds of the eyes were blind, necessitating early diagnosis and treatment.en_US
dc.identifier.affiliationsSmt. Kanuri Santhamma Centre for Vitreo-Retinal Diseases, Anant Bajaj Retina Institute, L V Prasad Eye Institute, Hyderabad, Telangana, India; Standard Chartered Academy for Eye Care Education, L V Prasad Eye Institute, Hyderabad, Telangana, Indiaen_US
dc.identifier.affiliationsSmt. Kanuri Santhamma Centre for Vitreo-Retinal Diseases, Anant Bajaj Retina Institute, L V Prasad Eye Institute, Hyderabad, Telangana, India; Jasti V Ramanamma Children’s Eye Care Centre, Child Sight Institute, L V Prasad Eye Institute, Hyderabad, Telangana, Indiaen_US
dc.identifier.affiliationsSmt. Kanuri Santhamma Centre for Vitreo-Retinal Diseases, Anant Bajaj Retina Institute, L V Prasad Eye Institute, Hyderabad, Telangana, Indiaen_US
dc.identifier.citationHansraj Saarang, Jalali Subhadra, Raval Vishal. Coats disease in infants, toddlers, and preschoolers: Clinical presentation and treatment outcomes. Indian Journal of Ophthalmology. 2025 May; 73(5): 672-678en_US
dc.identifier.issn0301-4738
dc.identifier.issn1998-3689
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/249892
dc.languageenen_US
dc.publisherWolters Kluwer – Medknowen_US
dc.relation.issuenumber5en_US
dc.relation.volume73en_US
dc.source.urihttps://doi.org/10.4103/IJO.IJO_2477_24en_US
dc.subjectClinical featuresen_US
dc.subjectCoats diseaseen_US
dc.subjectinfantsen_US
dc.subjectneonatesen_US
dc.subjecttreatmenten_US
dc.titleCoats disease in infants, toddlers, and preschoolers: Clinical presentation and treatment outcomesen_US
dc.typeJournal Articleen_US
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