DETECTION OF CARBAPENEMASE PRODUCING ENTEROBACTERALES AMONG THE CLINICAL ISOLATES OF DIARRHOEAGENIC ESCHERICHIA COLI CAUSING ACUTE GASTROENTERITIS IN CHILDREN BELOW 2 YEARS IN TERTIARY CARE HOSPITAL OF NORTH EAST INDIA.

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dc.contributor.authorMairembam, Preetaen_US
dc.contributor.authorDamrolien, Shanen_US
dc.contributor.authorDevi, Ksh. Mamtaen_US
dc.contributor.authorDevi, Kh. Sulochanaen_US
dc.date.accessioned2023-08-09T05:59:01Z
dc.date.available2023-08-09T05:59:01Z
dc.date.issued2022-08
dc.description.abstractIntroduction: Enterobacterales that test resistant to at least one of the carbapenem antibiotics (ertapenem, meropenem, doripenem, or imipenem) are called Carbapenem resistant Enterobacterales (CRE) and if they produce a carbapenemase (an enzyme that can make them resistant to carbapenem antibiotics) they are called Carpenemase producing Enterobacterales (CPE). Children with CRE strains in fecal samples are considered as a high risk group by World Health Organization (WHO), which can spread CRE by intimate contact and travel. This cross-sectional study was conducted in the Departm Methods: ent of Microbiology, RIMS, Imphal, Manipur, India from Jan 2020 to Feb 2022. A total of 157 children under 2 years of age whose stool culture was positive for diarrhoeagenic Escherichia coli were included in the study. The modified carbapenem inactivation method (mCIM) has been done for detection of carbapenemase producers and the addition of EDTA in eCIM to further differentiate between serine and metallo-?-lactamase producers. Out of 157 Result and Discussion: Diarrhoegenic E.coli (DEC) ,Carbapenem resistance was seen in 9 isolates i.e 5.7 %. Out of these 9 isolates, 3 were MBL producers tested by the phenotypic test mCIM and eCIM. All the three MBL producers carried bla NDM-1 gene. mCIM/eCIM assay is designed to simultaneously detect and distinguish the different types of carbapenemases. Carbapenemase genes are often located on plasmids that can be exchanged between Enterobacteriaceae and other Gram-negative bacteria. Carbapenem-resistant K. pneumoniae are currently more frequent and more likely to cause healthcareassociated outbreaks, carbapenem-resistant E. coli pose a greater risk for spread in the community. Conclusion: Screening for carbapenemase producer using mCIM and eCIM essay is important along with infection control measure such as active surveillance through rectal screening for CRE carriage on hospital admission, contact precautions, hand hygiene, patient isolation, environmental sanitation, case notification/fiagging, antibiotic restriction.en_US
dc.identifier.affiliationsPh.D Scholar, Department of Microbiology, RIMS, Imphalen_US
dc.identifier.affiliationsAssistant Professor Department of Microbiology, RIMS, Imphal *Corresponding Authoren_US
dc.identifier.affiliationsProfessor, Department of Microbiology, RIMS, Imphalen_US
dc.identifier.affiliationsProfessor, Department of Microbiology, RIMS, Imphalen_US
dc.identifier.citationMairembam Preeta, Damrolien Shan, Devi Ksh. Mamta, Devi Kh. Sulochana. EFFECT OF DIFFERENT NITROGEN SOURCES ON THE GROWTH OF FUSARIUM OXYSPORUM F. SP. CORIANDRII CAUSING WILT OF CORIANDER. Indian Journal Of Applied Research. 2022 Aug; 12(8): 39-41en_US
dc.identifier.issn2249-555X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/221241
dc.languageenen_US
dc.publisherIndian Society For Health And Advanced Researchen_US
dc.relation.issuenumber8en_US
dc.relation.volume12en_US
dc.source.urihttps://www.doi.org/10.36106/ijar/6901702en_US
dc.subjectmCIM and eCIMen_US
dc.subjectCREen_US
dc.subjectCPEen_US
dc.subjectNDM-1en_US
dc.titleDETECTION OF CARBAPENEMASE PRODUCING ENTEROBACTERALES AMONG THE CLINICAL ISOLATES OF DIARRHOEAGENIC ESCHERICHIA COLI CAUSING ACUTE GASTROENTERITIS IN CHILDREN BELOW 2 YEARS IN TERTIARY CARE HOSPITAL OF NORTH EAST INDIA.en_US
dc.typeJournal Articleen_US
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