The Design And Development Of Carvedilol Gastroretentive Floating Drug Delivery Systems Using Hydrophilic Polymers And In Vitro Characterization

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dc.contributor.authorMohapatra, P. K.en_US
dc.contributor.authorSatyavani, C. H.en_US
dc.contributor.authorSahoo, S.en_US
dc.date.accessioned2020-09-24T08:01:50Z
dc.date.available2020-09-24T08:01:50Z
dc.date.issued2020-07
dc.description.abstractObjective: The primary aim of the present examination was to create carvedilol phosphate floating tablets using factorial designs and for retention in the upper portion of the gastrointestinal (GI) tract to sustain the dissolution where the solubility of carvedilol phosphate is more in an acidic medium. Methods: The floating tablets of carvedilol phosphate were ready to employ different concentrations and a combination of these polymers of Na-alginate, Carbopol 934P, and sodium carboxymethyl cellulose (NaCMC) with lubricants magnesium stearate by direct compression technique. In the present experiment, involved sodium bicarbonate and citric acid as a gas-producing agent. Fifteen formulations structured and judged for pre-compression components like the angle of repose, bulk and tapped density, Hausner’s ratio, compressibility index, and post-compression factors are weight uniformity, hardness, drug content, friability, in vitro buoyancy, dissolution studies, and Fourier transforms infrared spectroscopy (FTIR). Results: The drug released 90.02% in 12 h by combining NaCMC (7.5 mg) and Na-alginate (7.5 mg) in the formulation F14 towards the achievement of sustained release. Batch F14 selected as optimized, as provided desired zero-order release profile as well as floating lag time 20 s and total floating time>12 h, and the mechanism of drug release observed (n = 1.098, super case-II transport). Conclusion: From the results fulfilled that all the preparation found to be within the pharmacopeia limits and was the best dosage form to treat moderate heart failure and hypertension. The in vitro dissolution profiles of all formulations placed into various kinetic models, the statistical parameters like slope, regression coefficient and intercept determined. The gastro-retentive dosage form to maintain the sustain drug delivery, which would improve the maximum therapeutic efficacy and patient compliance.en_US
dc.identifier.affiliationsMoradabad Educational Trust Group of Institutions Faculty of Pharmacy, Moradabad 244001, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsLydia College of Pharmacy, Ravulapalem 533238, Andhra Pradesh, Indiaen_US
dc.identifier.affiliationsC. U. Shah College of Pharmacy and Research, Surendranagar 363001, Gujrat, Indiaen_US
dc.identifier.citationMohapatra P. K., Satyavani C. H., Sahoo S.. The Design And Development Of Carvedilol Gastroretentive Floating Drug Delivery Systems Using Hydrophilic Polymers And In Vitro Characterization. International Journal of Pharmacy and Pharmaceutical Sciences. 2020 Jul; 12(7): 59-65en_US
dc.identifier.issn0975-1491
dc.identifier.issn2656-0097
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/206126
dc.languageenen_US
dc.publisherInnovare Academic Sciences Pvt. Ltd.en_US
dc.relation.issuenumber7en_US
dc.relation.volume12en_US
dc.source.urihttps://doi.org/10.22159/ijpps.2020v12i7.38024en_US
dc.subjectCarvedilol phosphateen_US
dc.subjectGastroretentive dosage formen_US
dc.subjectFactorial designen_US
dc.subjectDirect compression methoden_US
dc.titleThe Design And Development Of Carvedilol Gastroretentive Floating Drug Delivery Systems Using Hydrophilic Polymers And In Vitro Characterizationen_US
dc.typeJournal Articleen_US
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