Alterations in collagen metabolism in heart and kidney on dexamethasone administration in rats.

Simple item page
dc.contributor.authorRajashree, Sen_US
dc.contributor.authorPuvanakrishnan, Ren_US
dc.date.accessioned2009-05-28T11:17:31Z
dc.date.available2009-05-28T11:17:31Z
dc.date.issued2000-11-09en_US
dc.description.abstractTotal collagen content in heart decreased significantly till day 8 of dexamethasone (Dex: 2.5 mg/kg week; s.c. for 2 weeks) treatment and increased on withdrawal of Dex. Acid soluble collagen content in heart decreased till day 12 of Dex treatment, reached normal level on day 16 of Dex treatment and exhibited an increase thereafter. Pepsin solubilized fraction in heart also behaved similarly as the acid soluble fraction, but reached normal level on Dex withdrawal. The total collagen content and the acid soluble collagen in kidney decreased significantly throughout treatment as well as on Dex withdrawal whereas, the pepsin solubilized collagen fraction in kidney exhibited a significant increase from day 8 of Dex treatment and the level was maintained throughout the experiment. Incorporation of 14C-proline in both, heart and kidney was found to be reduced. Electrophoretic pattern of pepsin collagen solubilized fraction of heart and kidney revealed alterations in subunit composition and its types on Dex administration and withdrawal. Thus, administration of Dex induced alterations in the metabolism of collagen and on Dex withdrawal, the system slowly tended to attain normalcy.en_US
dc.description.affiliationDepartment of Biotechnology, Central Leather Research Institute, Adyar, Chennai 600 020, India.en_US
dc.identifier.citationRajashree S, Puvanakrishnan R. Alterations in collagen metabolism in heart and kidney on dexamethasone administration in rats. Indian Journal of Experimental Biology. 2000 Nov; 38(11): 1117-23en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/56510
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCollagen --metabolismen_US
dc.subject.meshDexamethasone --administration & dosageen_US
dc.subject.meshKidney --metabolismen_US
dc.subject.meshMaleen_US
dc.subject.meshMyocardium --metabolismen_US
dc.subject.meshProline --metabolismen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.titleAlterations in collagen metabolism in heart and kidney on dexamethasone administration in rats.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Indian Journal of Experimental Biology