Patho-Physiological Response of LPS Defective Brucella abortus S19Δper in Experimentally Infected Mice

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dc.contributor.authorSolanki, Khushal Singhen_US
dc.contributor.authorQureshi, Salauddinen_US
dc.contributor.authorKumar, Pawanen_US
dc.contributor.authorSahoo, Monalisaen_US
dc.contributor.authorM., Saminathanen_US
dc.contributor.authorU.K., Deen_US
dc.contributor.authorChaudhuri, Pallaben_US
dc.date.accessioned2020-10-16T08:58:36Z
dc.date.available2020-10-16T08:58:36Z
dc.date.issued2019-02
dc.description.abstractBrucellosis is an anthropozoonotic infectious disease in which infected animals pose a threat to humans. This disease has considerable social, economic and international trade importance. Despite past and current efforts to eradicate brucellosis, a large number of new human cases are reported annually worldwide. In this study, patho-physiological response to Brucella abortus S19Δper infection in BALB/c mice was assessed in comparison to its parent strain, B. abortus S19 and virulent strain, B. abortus 544. Immunohistochemical analysis confirmed the presence of bacteria in liver and spleen. Comparatively lower serum Aspartate aminotranferase (AST) level and observation of less number of microgranulomas in liver indicated that B. abortus S19 Δper was less infectious and failed to cause active infection unlike S19 and 544 strain. S19Δper, thus could be a safer vaccine candidate as an alternate to the S19 vaccine strain. Hematological studies indicated clinical manifestation of thrombocytopenia in different Brucella infected mice including S19Δper. Therefore, measurement of platelets count and serum AST level may offer as reliable indicators of brucellosis in clinical casesen_US
dc.identifier.affiliationsDivision of Veterinary Biotechnology, ICAR-Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh, INDIAen_US
dc.identifier.affiliationsDivision of Biological Standardization, ICAR-Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh, INDIAen_US
dc.identifier.affiliationsDivision of Veterinary Pathology,ICAR-Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh, INDIAen_US
dc.identifier.affiliationsDivision of Veterinary Pathology,ICAR-Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh, INDIAen_US
dc.identifier.affiliationsDivision of Veterinary Pathology,ICAR-Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh, INDIAen_US
dc.identifier.affiliationsDivision of Veterinary Medicine, ICAR-Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh, INDIAen_US
dc.identifier.affiliationsDivision of Bacteriology and Mycology, ICAR-Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh, INDIAen_US
dc.identifier.citationSolanki Khushal Singh, Qureshi Salauddin, Kumar Pawan, Sahoo Monalisa, M. Saminathan, U.K. De, Chaudhuri Pallab. Patho-Physiological Response of LPS Defective Brucella abortus S19Δper in Experimentally Infected Mice. Journal of Animal Research. 2019 Feb; 9(1): 79-85en_US
dc.identifier.issn2249-6629
dc.identifier.issn2277-940X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/210779
dc.languageenen_US
dc.publisherAssociation of Mastitisen_US
dc.relation.issuenumber1en_US
dc.relation.volume9en_US
dc.source.urihttps://dx.doi.org//10.30954/2277-940X.01.2019.11en_US
dc.subjectBrucellosisen_US
dc.subjectperosamine synthetaseen_US
dc.subjectlipopolysaccharidesen_US
dc.subjectthrombocytopeniaen_US
dc.subjectaspartate aminotransferaseen_US
dc.subjectmicrogranulomaen_US
dc.titlePatho-Physiological Response of LPS Defective Brucella abortus S19Δper in Experimentally Infected Miceen_US
dc.typeJournal Articleen_US
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