Evaluation Of Free Radical Scavenging Ability And Antiradical Activities Of Ximenia Caffra Fruit Extracts At Different Ripening Stages

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dc.contributor.authorMapunda, P. E.en_US
dc.contributor.authorMligo, C.en_US
dc.contributor.authorLyaruu, H. V. M.en_US
dc.date.accessioned2020-09-24T08:00:52Z
dc.date.available2020-09-24T08:00:52Z
dc.date.issued2019-01
dc.description.abstractObjective: To evaluate the free radical scavenging ability and antiradical activities of Ximenia caffra fruit extracts in their different ripening stages. Methods: Using standard procedures, Ximenia caffra fruit extracts were determined for ferrous ions chelating ability, nitric oxide and hydroxyl radical scavenging ability. Antiradical activities were assessed using 1,1-diphenyl-2-picrylhydrazyl (DPPH) in which the fruit extracts were evaluated for the number of antiradical units (AU515), the number of antiradical units per 1 mg of extracts (EAU515) and the total number of antiradical units per 1g of raw fruits (TAU515). Results: The fruit extracts exhibited significant higher ferrous ion chelating and free radical scavenging capacity compared to synthetic antioxidants (standard). Fruit extracts in early ripening stage (ERS) exhibited stronger ion chelation, nitric oxide and hydroxyl radical scavenging ability with low effective fruit extract concentration required to reduce free radicals by 50% (EC50) that were 14, 25 and 30µg/ml respectively than the late ripening stage (LRS) extracts. The fruit extracts also showed high AU515, EAU515 and TAU515. The values of AU515 ranged from 0.93 to 0.95, while EAU515 from 78.30 to 79.34 and TAU515 ranged from 19762.46 to 23821.23 of the extracts in LRS and ERS respectively. Conclusion: Based on these observations Ximenia caffra is potentially beneficial to human health due to its strong ability to scavenge free radicals. Its utilization can potentially reduce the risk of degenerative diseases to human beings.en_US
dc.identifier.affiliationsDepartment of Conservation Biology, University of Dodoma, Tanzaniaen_US
dc.identifier.affiliationsDepartment of Botany, University of Dar es Salam, Tanzaniaen_US
dc.identifier.affiliationsDepartment of Botany, University of Dar es Salam, Tanzaniaen_US
dc.identifier.citationMapunda P. E., Mligo C., Lyaruu H. V. M.. Evaluation Of Free Radical Scavenging Ability And Antiradical Activities Of Ximenia Caffra Fruit Extracts At Different Ripening Stages. International Journal of Pharmacy and Pharmaceutical Sciences. 2019 Jan; 11(1): 55-60en_US
dc.identifier.issn0975-1491
dc.identifier.issn2656-0097
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/205870
dc.languageenen_US
dc.publisherInnovare Academic Sciences Pvt. Ltd.en_US
dc.relation.issuenumber1en_US
dc.relation.volume11en_US
dc.source.urihttps://doi.org/10.22159/ijpps.2019v11i1.29065en_US
dc.subjectAntiradical activityen_US
dc.subjectiron chelationen_US
dc.subjectradical scavengingen_US
dc.subjectripening stagesen_US
dc.subjectXimenia caffraen_US
dc.titleEvaluation Of Free Radical Scavenging Ability And Antiradical Activities Of Ximenia Caffra Fruit Extracts At Different Ripening Stagesen_US
dc.typeJournal Articleen_US
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