Mitochondrial Reactive Oxygen Species and Nephrolithiasis

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dc.contributor.authorSharma, Minuen_US
dc.contributor.authorS.Naura, Amarjiten_US
dc.contributor.authorSingla, SKen_US
dc.date.accessioned2020-04-23T07:26:20Z
dc.date.available2020-04-23T07:26:20Z
dc.date.issued2019-12
dc.description.abstractMitochondrial redox/oxidative balance are vital for cellular life and death. Mitochondria are considered as the most important sub cellular site of reactive oxygen species production in mammalian organs. Reactive oxygen species produced by mitochondria can cause damage to mitochondrial components and initiate degradative processes. The kidney requires ample amount of mitochondria to remove waste from the blood and regulate fluid and electrolyte balance. Adverse conditions of organelle stress such as decreased altered energy metabolism in mitochondria contribute in the progression and development of kidney diseases. Nephrolithiasis is a kidney disease in which solid urinary components form crystals, precipitated out of the urine and shaped into stones. Studies have suggested that oxidative stress and associated renal injury paved the way for crystal deposition in the renal tissue. Mitochondria are anticipated as the foremost source of intracellular reactive oxygen species under oxalate induced nephrolithiasis. Persistent mitochondrial dysfunction results in the progression of nephrolithiasis. Although different approaches to minimize mitochondrial dysfunction through regulation of mitochondrial ROS production using antioxidants have been accomplished yet mitochondria specific antioxidants are the prerequisite. This review offers a glimpse into the role of mitochondrial reactive oxygen species in nephrolithiasis and the future perspective of potential antioxidant therapies.en_US
dc.identifier.affiliationsDepartment of Biochemistry, Panjab University, Chandigarh, Indiaen_US
dc.identifier.citationSharma Minu, S.Naura Amarjit, Singla SK. Mitochondrial Reactive Oxygen Species and Nephrolithiasis. International Journal of Applied Biology and Pharmaceutical Technology. 2019 Dec; 10(4): 71-84en_US
dc.identifier.issn0976-4550
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/198220
dc.languageenen_US
dc.publisherInternational Journal of Applied Biology and Pharmaceutical Technologyen_US
dc.relation.issuenumber4en_US
dc.relation.volume10en_US
dc.source.urihttps://www.doi.org/10.26502/abmb.009en_US
dc.subjectMitochondriaen_US
dc.subjectKidneyen_US
dc.subjectHyperoxaluriaen_US
dc.subjectNephrolithiasisen_US
dc.subjectReactive oxygen speciesen_US
dc.subjectAntioxidantsen_US
dc.titleMitochondrial Reactive Oxygen Species and Nephrolithiasisen_US
dc.typeJournal Articleen_US
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