Interaction of ethanol and ascorbic acid on lipid metabolism in guinea pigs.

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dc.contributor.authorSuresh, M Ven_US
dc.contributor.authorLal, J Jen_US
dc.contributor.authorKumar, Sen_US
dc.contributor.authorIndira, Men_US
dc.date.accessioned2009-05-28T10:56:10Z
dc.date.available2009-05-28T10:56:10Z
dc.date.issued1997-10-25en_US
dc.description.abstractInfluence of excessive intake of ascorbic acid (AA) on alcohol induced hyperlipidemia was investigated. In the present study four groups of male guinea pigs were maintained for 30 days as follows: (1) Control group (1 mg AA/100 g body wt). (2) Ethanol group (I mg AA + 9 g ethanol/100 g body wt). (3) AA group (25 mg AA/100 g body wt). (4) AA + Ethanol group (25 mg AA/100 g body wt + 9 g ethanol 100 g body wt). It was shown that tissue ascorbic acid concentration increased with the intake of mega dose of AA. Alcohol administration depleted tissue ascorbic acid content. But coadministration of AA and alcohol enhanced AA levels in comparison with the ethanol group. Alcohol induced hyperlipidemia was reduced in almost all the tissues by the intake of ascorbic acid. This was observed to be due to increased hepatic catabolism of cholesterol to bile acids. However cholesterogenesis was enhanced as evidenced by the increased HMG CoA activity. Thus the results indicate that the mega dose of AA ingestion is beneficial in reducing alcohol induced hyperlipidemia and AA deficiency.en_US
dc.description.affiliationDepartment of Biochemistry, University of Kerala, Thiruvananthapuram, India.en_US
dc.identifier.citationSuresh MV, Lal JJ, Kumar S, Indira M. Interaction of ethanol and ascorbic acid on lipid metabolism in guinea pigs. Indian Journal of Experimental Biology. 1997 Oct; 35(10): 1065-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/56006
dc.language.isoengen_US
dc.source.urihttps://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijeb/ijeb0.aspen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAscorbic Acid --pharmacologyen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshEthanol --pharmacologyen_US
dc.subject.meshGuinea Pigsen_US
dc.subject.meshLipids --blooden_US
dc.subject.meshMaleen_US
dc.titleInteraction of ethanol and ascorbic acid on lipid metabolism in guinea pigs.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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